Posted on 01/20/2022 8:43:37 AM PST by ConservativeMind
A research team discovered that orally administrated bismuth drug colloidal bismuth subcitrate (CBS) together with N-acetyl cysteine (NAC) could be a broad-spectrum anti-coronavirus cocktail therapy.
Oral administration of the cocktail suppresses the replication cycle of the virus, reduces viral loads in the lung and ameliorates virus-induced pneumonia in a hamster infection model. Not only could NAC stabilize bismuth-containing metallodrugs at stomach-like conditions but also enhance the uptake of bismuth drugs in tissues (e.g. lung) and antiviral potency through oral administration. Bismuth subsequently suppressed virus replication of a panel of clinically relevant coronaviruses, including Middle East respiratory syndrome-related coronavirus (MERS-CoV), Human coronavirus 229E (hCoV-229E) and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its alpha variant (B.1.1.7) by inactivating multiple essential viral enzymes.
RBC, as well as other related bismuth drug(s), e.g., colloidal bismuth subcitrate (CBS) and bismuth salicylate (BSS), acts to precipitate in gastric juice and form a protective coating on the gastric wall, which leads to a hindered absorption in gastrointestinal tract. The findings revealed that NAC could prevent the hydrolysis of CBS in simulated gastric juice buffer (pH 1.2) and sodium bicarbonate buffer (pH 9.2), which form a highly stable and water-soluble Bi(III) thiolate complex, [Bi(NAC)3]. The combined use of NAC could significantly enhance the permeability of bismuth in parallel artificial membrane model, the human intestinal epithelial cancer cell line (Caco-2) model, and a modified ex vivo everted rat gut sac model. The in vivo pharmacokinetics data also consistently demonstrate that compared with the administration of CBS in the absence of NAC, the co-administration of CBS with NAC led to a remarkably improved bismuth uptake profile in both blood and lung tissues.
The therapeutic dosage of drugs induced only reversible nephrotoxicity and no systematic toxicities.
(Excerpt) Read more at medicalxpress.com ...
The biotechnocrats have really goofed up, so many simple treatments defeat it, only those hypnotized are being culled, the free will survive.
So will Pepto Bismol work, it’s Bismuth Subsalicylate. Hmmmm…
OMG - Bismuth is used in ammunition! So, first you want me to take horse de-wormer and now you want me to eat bullets!
/s
Ive been taking NAC for years before the Rona. It clears the lungs pretty good. It takes 3 or4 days to build up and kick in so its much better is taken daily.
So basically everything works against COVID, i.e. COVID is the common cold and eventually goes away on its own.
Whiskey and honey.
No Matt !
There is a difference between lead, and the explosive used to "Send IT".
Go ahead and take it. Just don't fart in the direction of your neighbor at 2450 fps in the direction of your neighbor,
or you might hurt your reputation.
They knew about the CBS, back in September....
https://pubs.rsc.org/en/content/articlepdf/2021/sc/d1sc03526f
Non patentable medicines need not apply
“The therapeutic dosage of drugs induced only reversible nephrotoxicity”
I think they should have elaborated on that bit.
“OMG - Bismuth is used in ammunition! So, first you want me to take horse de-wormer and now you want me to eat bullets! /s”
You can take the easy way or the hard way! :-)
It is listed as a similar substance, but no true equivalence is described.
Still, it would seem an opportunity to explore.
Isn’t Pepto Bismal “bismuth”?
NAC and glycine are the correct combination to increase glutathione to youthful levels. Glutathione is the master anti oxident. It goes into decline after age 45.
Have you read as to the correct doses for NAC and glycine?
I think that guy ended up dying. IIRC, it was the after effects of covid that caused him to commit suicide
Pepto Bismol?
I do know NAC can interfere with processes other antioxidants perform.
Is that type of bismuth available without prescription?
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