Posted on 01/25/2022 7:07:24 PM PST by ConservativeMind
A composite score can identify patients with chronic lymphocytic leukemia (CLL) with very low risk for requiring treatment, according to a study published online Jan. 14 in the European Journal of Haematology.
Christian Brieghel, M.D., Ph.D., from Rigshospitalet in Copenhagen, Denmark, and colleagues developed and validated a prognostic index to identify newly diagnosed CLL patients without need of treatment (WONT) by a training/validation approach based on data from 4,708 patients. Composite scores were derived from weighted hazards to define CLL-WONT risk groups.
The researchers observed independent associations for age (older than 65 years: 1 point), Binet stage (2 points), lactate dehydrogenase (>205 U/L: 1 point), absolute lymphocyte count (15 to 30 x 109/L: 1 point; >30 x 109/L: 2 points), β2-microglobulin (>4 mg/L: 1 point), IGHV mutation status (unmutated: 1 point), and 11q or 17q deletion (1 point) with shorter time to first treatment (TTFT). Five-year TTFT of 2 percent and 7 to 19 percent was seen for low-risk patients by internal validation and by external validation, respectively. The five-year TTFT was 10 percent for the 756 CLL-WONT low-risk patients, including all patients with complete scores, and it was 8 percent for the 704 patients who were low risk according to both CLL-WONT and the international prognostic index in CLL.
"We here present a novel prognostic index, CLL-WONT, enabling identification of patients with very low risk of ever requiring treatment," the authors write.
(Excerpt) Read more at medicalxpress.com ...
They might not need treatment - according to the index - but will that prevent them from asking for it anyway?
I have it. It tried to kill me. Did six cycles of chemo to knock it back. So far, so good.
bfl
Wow, hang in there! I can’t imagine what you’ve been going through.
God Bless!
Pete
Had people praying for me, and God answered their prayers.
🙏🙂
I have a version of this cancer called Mantle Cell Lymphoma. I went to the #1 cancer center in the country where they see these types of cancer every day. Most onc docs just don’t have the experience. So, they go to a recipe book for your diagnosis and treatment. That does not always turn out too well.
My step-dad has had it for years. I think he did some mild chemo treatments, but had a bad flare up a few years back and we almost lost him.
He now takes an experimental pill that is ridiculously expensive, but it seems to be keeping everything in check.
My Dad got it and they said most people live with it for 10 years or so. He died in 2.
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