Posted on 01/29/2022 7:10:33 PM PST by ConservativeMind
Beta-blockers are a group of drugs that slow down our heart rate. They work by blocking the action of stress hormones—adrenaline, noradrenaline—stopping them from binding to receptors on heart cells.
Because they reduce the rate at which the heart contracts, beta-blockers are a common prescription for treating numerous heart conditions, such as angina, high blood pressure and heart failure.
A new study led by Dr. Javier Barallobre-Barreiro has discovered another way that beta-blockers may benefit patients with heart failure. Specifically, they help to reduce the levels of a type of proteoglycans (a hybrid molecule made of protein and carbohydrates) called CSPGs.
CSPGs are found in the heart tissue and are important for the function of the extracellular matrix (ECM). The ECM is the heart's structural scaffold, allowing neighboring heart cells to connect and communicate with each other.
However, problems arise if there are too many CSPGs within the heart, as they change the structure of the ECM. Analyses of heart tissue from patients with heart failure found a significant deposit of CSPGs within their samples.
When the authors increased CSPGs in mouse models, they found that it reduced the efficiency of the heart in pumping blood to the body. This suggests that an overabundance of CSPGs is detrimental for the heart.
Patients who used beta-blockers had a lower heart rate, as expected. But they were also found to have less CSPGs in the ECM. Follow-up experiments on beta-blockers demonstrated that they block hormone receptors in fibroblasts (the cells that produce the ECM), reducing CSPG production.
Further research is needed to understand how changes in CSPG deposition impair heart function, and how such changes can help scientists find new therapeutic targets that decrease the risk of heart failure and improve the quality of life of patients with heart failure.
(Excerpt) Read more at medicalxpress.com ...
Maybe this shows a reason to shake that up, or add it as a low dose option while reducing the potency of one of the others ones you may already be taking.
bkmk
In my case I've been taking all of the above for about 30 years.
I just throw a handful on my cereal and call them lucky charms.
Funny how those drugs are also given to animals, but you never hear the liberal saying that beta-blockers and such are “cat and dog medications”, just like they’ve disparaged Ivermectin as “horse paste”.
Lucky Charms ,Ha !
.
I used to wake then lite
Up a bowl of Fruit Loops!
.
Seriously, I’m on betaBlockers ,Plavix.
Just Retired and thinking to revisit the Whole idea.
Who knows,Doctors and needles are scary.
A single pill, beta blocker (Benicar), took my asymptomatic high bp from around 190/115 to a regular 110/65. Been with it for 16 years now, at 53 no other prescriptions are necessary, just do a couple vitamins. Nice to hear there could be some other positive.
I've been retired exactly 1 year and doing fine.
I know what you mean about the doctors. Half the time it seems like they just stumble around until they find something that works. I've always done my own research and don't just take a doctor's word for it, and I listen to what my body tells me.
I won't stop the BP mess though. I feel it when I'm late taking them. Got a family history and have had high BP since I was a teen. Didn't start the meds until I was in my mid 20s though.
Same for me. I had a doctor one time who thought I should stop the calcium channel blockers and just take the bata blockers. I was on both. But it turned out to be a mistake. I started getting dizzy and almost feinting. (Near syncopy) They put me back on the Ca channel blocker and I was back to normal in a day. I have since asked for both the medicines even though the cardiologist told me that they usually only go with one drug since they both slow the heart rate.
But I have been happy on the regimine of both pills. BTW, another thing that took a long time to discover was my low O2 at night. It turns out I have sleep apnea and when asleep I relax my lower jaw (mouth breather) This was a very serious find, as I am getting stronger each month since I have a ventilator too.
They don’t call it practicing medicine for nothing. They experiment and you’re the test subject. Most I’ve know are good people and do their best, but after all they’re just people. Always question and don’t follow their prescriptions blindly.
Beta-blockers stopped my daughter’s frequent migraines.
I used to Trust our
Medical System implicitly.
Now they are lower
Than Lawyers.
Stopped migraines..
Same, had food sensitivity triggers for ten years, gone within six weeks, now twenty years on , still taking
“A single pill, beta blocker (Benicar)…”
**************************************
Benicar is an ARB, not a beta blocker.
Well.....damn. Thank you for making me read more about it. Talk about ignorance all this time. Medicine and the medical field are not my thing.
I never thought I would be jealous of those on Beta blockers and or the Calcium channel blockers. My BP has been 128/65 as long as I can remember.
Now if someone can point me to a pretty older lady with parkinsons. Dates to the drive in theater will be better than ever.
(Hint) That last bit was a joke..
I took one for a while everyday at about 07:15. By 10:30, I could barely keep my eyes open at work. Told my Doctor. He said to take them at night just before bedtime. Best sleeping pill ever, though I have only taken a sleeping pill a half dozen times in my life, all while as an In-Patient.
I don't care for that next day hangover.
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