Drug halts immune reactions to save damaged lungs (Cheap Disulfiram stops ARDS conditions)

Medical Xpress / Cold Spring Harbor Laboratory / JCI Insight ^ | Feb. 8, 2022 | Jose M. Adrover, et al

[ConservativeMind]

A team discovered disulfiram, an FDA-approved drug, prevents the immune system from producing toxic webs known as neutrophil extracellular traps (NETs). Many suspect NETs help drive the development of acute respiratory distress syndrome (ARDS) in patients with severe COVID-19 and other life-threatening lung injuries.

Jose M. Adrover, postdoctoral fellow, explains that NETs are usually released during infections when immune cells, called neutrophils, confront a threat that is too large for the tiny cells to battle directly. To extend their reach, neutrophils spew a sticky web of DNA and toxins, which indiscriminately poisons pathogens and the body's own cells. "They will damage everything, all around," Adrover says.

Because NETs can be so destructive, researchers in Egeblad's lab have been searching for ways to block their formation. Disulfiram, which has been used since the 1950s as a treatment for alcohol use disorders, was a promising candidate. "Disulfiram interferes with gasdermin D, a molecule needed to produce NETs", says Juliane Daßler-Plenker, a postdoctoral fellow.

The team investigated disulfiram's effects on NET production. They found that the drug prevents neutrophils isolated from blood from generating NETs. "By computerized tomography [CT scan], we saw a stark reduction of edema [fluid] in the lungs, and the drug dramatically improved survival," says Scott Lyons. Robert Schwartz's team tested disulfiram in hamsters infected with the SARS-CoV-2 virus; NET production was blocked and lung injury was reduced.

Disulfiram is the first FDA-approved drug that can block NET formation. This study dissects the drug's ability to block NETs and change immune signaling in a way that may be beneficial for treating severe COVID-19.

Clinical trials investigating disulfiram's use in patients with COVID-19 are underway. Egeblad says, "…we now have a tool to help us study the complex roles of NETs in lung injury, cancer, and other diseases that involve NETs."

[ConservativeMind]

This might be something to give your doctor, should you or someone you know likely have ARDS.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Please email or private message me if you want on or off of this list.

[Bloody Sam Roberts]

A team discovered disulfiram, an FDA-approved drug

Probably not for long given the way things are going and the US Gubmint's complicity in the whole Covidiocy affair.

[cough, cough...ivermectin...cough, cough]

[DannyTN]

Brand Name: Antabuse

I’m going to take up drinking to have some on hand. /jk

One positive of covid is that there has been a lot of advances in medical knowledge.

[nh1]

Disulfiram is also used off label for Lyme. It's what finally cleared the Lyme out of my system.

Seems to be another of the inexpensive miracle drugs.

I hope it doesn't get cancelled like Ivermectin and hydroxychloroquine. Those medicines are also used effectively for Lyme and co-infections.

[Worldtraveler once upon a time]

--- "A team discovered disulfiram, an FDA-approved drug. Probably not for long given the way things are going and the US Gubmint's complicity in the whole Covidiocy affair. [cough, cough ...ivermectin ...cough, cough]"

Given the off-label use opposition for ivermectin which is beginning to show positive effects in the treatment of cancers, one will watch the FDA to take some stance shortly.... This will tell much.

Disulfiram, first patented in 1952.

https://www.drugpatentwatch.com/p/generic-api/DISULFIRAM

[smileyface]

One positive of covid is that there has been a lot of advances in medical knowledge.
```````
One positive of covid is that there has been a lot of revealing of hidden medical knowledge.

[ETCM]

Probably just some Translational Pharmaceutical folks figured this out in silico, but I have to wonder if someone noticed chronic alcoholics were not getting severe covid? Some folks who have dealt with alcoholics might know this drug as Antabuse.

[ProtectOurFreedom]

"...disulfiram is an FDA-approved drug"

So are IVM and HCQ.

The label says "Disulfiram is an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage."

So, following the precedents set for IVM and HCQ, using Disulfiram off-label to treat ARDS should be banned by the FDA, right?

Disulfiram Label

[palmer]

Over a year ago: https://link.springer.com/article/10.1007/s11739-021-02633-y

Laboratory-confirmed COVID-19 (N = 10, 0.77%), hospitalization due to confirmed COVID-19, and pneumonia were less, but not significantly, common in disulfiram group. Symptoms compatible with COVID-19 were significantly less common in disulfiram group (Table 1).

[MHGinTN]

How long before the regime bans this drug ... so the genocide can continue as planned?

[Thommas]

This tool will never see the light of day.