Cancer: When viruses and bacteria cooperate (Curing chlamydia prevents HPV cervical cancers)

Medical Xpress / Nature Communications / University of Würzburg ^ | Feb. 24, 2022 | Stefanie Koster et al

[ConservativeMind]

Patients who develop cervical cancer are often infected not only with the human papillomavirus (HPV) but also simultaneously with the bacterial pathogen Chlamydia trachomatis. The suspicion is, therefore, that the two pathogens work together as a kind of team to "reprogram" the cells they infect in such a way that they degenerate and multiply uncontrollably.

Dr. Cindrilla Chumduri has now demonstrated for the first time that this is a concretely verifiable effect.

HPV and chlamydia: A malicious alliance driving cellular transformation

Virus DNA can be found in more than 90% of all cervical cancers. However, they are not the sole culprit, as shown by the fact that although more than 80% of women become infected with HPV during their lifetime, not even 2% develop cancer. Coinfection with C. trachomatis is therefore thought to be a major cofactor in driving malignant tissue formation.

The problem is that "unlike tumor viruses, whose DNA can be found in tumors, bacteria associated with cancer rarely leave detectable elements in cancer cells," explains Chumduri. Nevertheless, to link bacteria to cancer development, she said, it is necessary to identify those cellular and mutational processes that contribute to cells undergoing pathological changes. Chumduri and her team have now systematically decoded precisely these processes in the organoids they have developed.

The result: "Our analyses show that HPV and chlamydia cause a unique cellular reprogramming of the host," explains the scientist. Several genes are up-or down-regulated by the two pathogens in different ways, which is associated with specific immune responses. Among other things, pathogens influence a significant subset of all regulated genes responsible for DNA damage repair.

Overall, the findings show that "co-persistence of HPV and chlamydia in a stem cell could adversely affect cellular and genomic stability and promote neoplastic progression," as the study concludes.

[ConservativeMind]

Our bodies can clear HPV out of the body, most of the time.

Chlamydia can definitely be cured, however, and appears to be what often nudges HPV into starting cervical cancer.

[ConservativeMind]

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[Mount Athos]

Hep C causes liver cancer too

[ConservativeMind]

This is HPV, not “C.”

[Mount Athos]

I wasn’t trying to say that Hepatitis C and HPV were the same thing, my intention was to say that there is another Virus that also causes cancer.

[Drago]

Uh oh...you opened a can of worms! FR antivaxxers may see this...(government mandated HPV vaccine shots for teen/6th grade girls).

https://www.npr.org/2011/09/16/140530716/in-texas-perrys-vaccine-mandate-provoked-anger

https://www.cdc.gov/vaccines/parents/diseases/hpv.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708146/

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60475-9/fulltext

https://hub.jhu.edu/2018/10/24/why-parents-refuse-hpv-vaccine/

etc., etc.