The Evaluation of Glutathione Reductase and Malondialdehyde Levels in Patients With Lumbar Disc Degeneration Disease

In Vivo Journal ^ | May 2019 | SELVI DUMAN BAKIREZER et al

[ConservativeMind]

Background/Aim: Increased oxidative stress plays a crucial role in pathogenesis of various diseases. The present study aims to investigate glutathione reductase (GR) and malondialdehyde (MDA) enzymes as markers of oxidative stress mechanisms in lumbar disc degeneration disease (LDDD).

Patients and Methods: The study group consisted of 39 patients diagnosed with LDD and 37 healthy individuals in the control group. The enzyme-linked immunosorbent assay (ELISA) method was used to determine serum GR and MDA levels in the two study groups.

Results: Serum GR levels were significantly lower (p=0.008), while MDA levels were significantly higher in the patient group compared to the controls (p=0.025). Conclusion: Oxidative stress mechanisms play a crucial role in disc degeneration and GR deficiency could be an eligible risk factor for LDDD.

Low back pain and lumbar disc herniation are major problems in industrialized societies especially, hindering the labor force in the modern way of living. Despite the advances in treatment, total recovery remains impossible for these disorders. Hence, multidisciplinary diagnostic methods and multimodal treatment are needed in order to better treat low back pain

Besides several biomechanical and biochemical changes involved in intervertebral disc degeneration; several intrinsic, extrinsic, and genetic factors play a role in its development. Compression, torsional injuries, overloads, and congenital anomalies in the spinal column result in disc degeneration due to over-compression of the intervertebral disc. Furthermore, disruption of the nutritional support of the disc may aggravate the degeneration. Although there are several available studies on disc degeneration in the literature, the physiopathology and etiology of disc degeneration is not completely understood.

Found in high concentrations in all prokaryotic and eukaryotic cells; glutathione (GSH) is a tripeptide synthesized from glutamic acid, cysteine, and glycine (7). Glutathione protects the cell against the noxious effects of oxidized molecules with the -SH groups in its structure.

[ConservativeMind]

It is not easy to get nutrients into spinal discs, but it does appear disc cells do generate glutathione from what nutrients they do receive.

Glutathione is generated through a complex process, but there are a few known ways to help encourage this process. One, is by being young, as your body easily creates glycine and cysteine, two conditional amino acids that are crucial to the glutathione process.

For older adults, this process starts breaking down. Scientists have found we can reinitialize the creation of glutathione by supplementing with equal parts glycine and N-acetyl-cysteine (NAC). These work together to heal the missing parts of broken glutathione process in older adults. Several study writeups on “GlyNAC” have been previously posted (search in the title or for the keyword) for insights on this.

There is a supplement called “glutathione reduced,” which is apparently the only form that can successfully make it through your stomach. Some studies show that also works.

The difference between GlyNAC and the “glutathione reduced” is that the GlyNAC allows your cells to make it where it is already known to need it, while the glutathione reduced would have to “find its way” to the right places. This would tend to be less useful.

This study is one of several (the others I saw didn’t have a free journal version) discussing the importance of glutathione in preventing back issues with disc degeneration.

I hope it can help a few here with back issues. I will say that GlyNAC has been shown to revitalize mitochondria, bringing the cell they are within, back to life, as well.

[ConservativeMind]

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[ConservativeMind]

Other back disc studies, but only their abstracts are free:

Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis

https://pubmed.ncbi.nlm.nih.gov/24409809/

Oxidative stress participates in age-related changes in rat lumbar intervertebral discs

https://pubmed.ncbi.nlm.nih.gov/25081833/

[KingLudd]

Oh, jeeze. Better get ready to read 30 replies detailing freeper back issues. /s

[Captainpaintball]

Just a note. Keep posting this stuff. This is not one of those lists that will get you big reply numbers like "LetS g0 BrAndOn!" bait threads. Don't get discouraged if there are only one or two replies. At least you are not spamming the reply threads with fake replies and pictures of cats and lists of rules and bumps and other horsecrap like the Q-tard losers do.

You are doing a real service here. Keep it up!

[goodnesswins]

Yes...to what CaptainPaintball said...!!!!!

[Conservative4Life]

Could this be the relief asked for? without surgery and high percentage of paralysis?

[Harmless Teddy Bear]

Thanks I will add glycine to our daily. We already take NAC. Anything to get the old back working better!

Does it need to be exactly a one to one ratio?

[ConservativeMind]

It is safest to have more glycine, if erring on a side.

[Harmless Teddy Bear]

Thank you!

[ConservativeMind]

Ping to you.

[NetAddicted]

Peruse later.