Posted on 01/15/2023 9:07:10 PM PST by ConservativeMind
New research finds that immune checkpoint (PD-1) inhibitors prior to surgery was strikingly effective for patients with localized mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC).
Nearly all of the patients studied benefitted from neoadjuvant PD-1 inhibitors, with 1-of-4 experiencing complete response on clinical assessment. In addition to the short-term effectiveness, the findings showed substantial longer survival benefits from neodjuvant PD-1 inhibitors, including a low recurrence rate when compared with historic rates.
The study included a retrospective review of 73 patients between ages 18 and 75 with confirmed dMMR/MSI-H CRC who received any type of PD-1 inhibitor prior to surgery between October 1, 2017 and December 31, 2021. Of those 73, 48 were diagnosed with colon cancer, 18 with rectal cancer, and 7 with multiple types of CRC. 84.9% overall experienced an objective response, with 23.3% showing complete response and 61.6% partial response.
The 2-year rates for tumor-specific overall survival and disease-free survival were 100% for patients who underwent surgery after PD-1 blockade.
"I think care providers, especially surgeons, should refrain from scheduling immediate surgery for patients with locally advanced, or even early-stage dMMR/MSI-H colorectal cancer. With such a powerful option at hand, we have the duty to offer a safer surgery with better outcomes or a non-surgical-yet-equally-effective approach for this group of patients, especially for those who might suffer from function damage or organ sacrifice after surgery."
The study had an average follow-up time of 17.2 months, with 16 patients tracked for more than two years. The researchers call for more studies with an even longer follow-up to confirm these results, especially after treatment ends. There is also more to learn about the long-term safety of this approach and possible implications for limiting or avoiding surgery entirely.
(Excerpt) Read more at medicalxpress.com ...
doesn’t mention what stage of cancer they were that were tested?-
It may have said, but I didn’t see how the immunotherapy is administered. IV? Injections? Oral?
Also, since Ivermectin seems to have been helpful in treating, even curing, some cancers, I’d be popping that right away.
There appears to be a lot of research showing that Ivermectin treats / cures colon cancer. Here’s a link to search results; too many good items to list here separately.
https://presearch.com/search?q=%22colon+cancer%22+ivermectin
Side note: I recently discovered that Presearch.org does not censor / block research about IVM, so I’ve been using it exclusively. IVM also treats ALS / motor neuron disease, diverticulitis, hypertension, and a host of other diseases and conditions. Again, all this shows up in Presearch.org results.
At 76 years of age my Dr wants me to go in for a colonoscopy and I have refused.
The average colonoscopy is a one day affair in which you go home when done.
With me it is different as I am on a high dose of warfarin for an artificial heart valve.. I would have to go in five days ahead of time, get off warfarin and on to Heparin. Then have the colonoscopy done with emergency tools for sudden quick bleeding.
When done I would have to stay in the hospital for another 5 or so days to get off Heparin and back on to warfarin.
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