Many of those with experience know someone with problems in the area of addiction.
One notices that it is clearly intertwined with other issue directly related. Such as a person starts having anxiety, it grows, and the person relapses(self medicates) Same for the other issues.
There is a similar pattern with OCD. I have a family member who suffers from at times debilitating OCD. And each episode is ‘kicked off’ by a ‘change of life’ / transition event. Not sure if that’s the exact thing you’re talking about, but it sounds like the kind of experience we’ve encountered.
Many people who were adopted have an actual change to the brain development from that early trauma ( especially if the had neglect in an orphanage or abuse). It would be wonderful if this research can someday help them physically heal those parts of the brain because many suffer lifelong issues of various types, even if they had a good childhood after adoption. I think most “counseling” in these cases makes the resulting issues worse.