Posted on 01/21/2023 12:20:18 PM PST by ConservativeMind
Researchers have found that vitamin D may be metabolized differently in people with an elevated body mass index (BMI). The study is a new analysis of data from the VITAL trial that investigated taking vitamin D or marine omega-3 supplements.
"The analysis of the original VITAL data found that vitamin D supplementation correlated with positive effects on several health outcomes, but only among people with a BMI under 25," said first author Deirdre K. Tobias, ScD. "There seems to be something different happening with vitamin D metabolism at higher body weights, and this study may help explain diminished outcomes of supplementation for individuals with an elevated BMI."
While the trial found little benefit of vitamin D supplementation for preventing cancer, heart attack, or stroke in the overall cohort, there was a statistical correlation between BMI and cancer incidence, cancer mortality, and autoimmune disease incidence.
"Most studies like this focus on the total vitamin D blood level," said senior author JoAnn E. Manson, MD, DrPH. "The fact that we were able to look at this expanded profile of vitamin D metabolites and novel biomarkers gave us unique insights into vitamin D availability and activity, and whether vitamin D metabolism might be disrupted in some people but not in others."
The researchers found that vitamin D supplementation increased most of the biomarkers associated with vitamin D metabolism in people, regardless of their weight. However, these increases were significantly smaller in people with elevated BMIs.
"We observed striking differences after two years, indicating a blunted response to vitamin D supplementation with higher BMI," Tobias said.
"This study sheds light on why we're seeing 30–40% reductions in cancer deaths, autoimmune diseases, and other outcomes with vitamin D supplementation among those with lower BMIs but minimal benefit in those with higher BMIs," said Manson.
(Excerpt) Read more at medicalxpress.com ...
Like nearly everything else in our culture, everything has to fit in a specific pigeon hole or it is wrong. No flexibility in critical thinking or gray areas. Go to one of your local government schools and peruse a copy of the school's student manual. Western health care is the same way. Stratified and inflexible.
My wife would be dead now if our family doctor followed the book on everything.
Lost 80 pounds and the chronically low vitamin D level corrected itself without supplementation.
So if you get your BMI back under 25 does it come back or, like diabetes, you’re always having troubles metabolizing vitamin D?
What diet did you use?
I think it’s 25 for men? I just read this on daily mail yesterday I think.
I started D3 recently and seems to be helpful through the dark months. I’ll probably oh take it year round just amazoned a new batch
In a hundred different ways obesity is suicide.
I use a daily 10000IU D3, 500 mcg K2, 400 mg magnesium and stay away from high fructose corn syrup. I overshot my target and had a blood vitamin D at 170 ng/ml. My doctor recommended reducing to a 5000IU D3 daily and get the blood level below 120 ng/ml.
I just recovered from COVID case #2. I had it in January 2022 and now in January 2023. Unvaxxed. Outwardly, just a bad cold this time. The trailing end comes with lots of post nasal drip and coughs. Managing with dextromethorphan, guiafenisin and phenylaphrine HCL (Mucinex).
D3 is a fat soluble vitamin. So if you are fat or have lots of fat, your D3 gets locked up in that blubber. So take more D3 and lose weight. I would say obese people can easily take 10000 units D3 daily. Get your D3 levels checked in your common bloodwork.
I get tired of hearing about BMI. I get a mandatory test at work for insurance purposes. Mine is 25 on the nose and their last response after testing is that I should lose some.
Here are their targets
body fat percentage 20
waist size 38
I’m going to be 66, 33 in waist, 5’9 170 and 13 percent body fat, I’m an ex college athlete and work out 5 days a week, run, hump weights and haven’t taken a daily prescription in my life.
The last nurse that told me I probably should lose some was about 5’2 185!
If I had a 36 inch chest, I might be too heavy at 170, but I’d be a scarecrow at 160.
My 50 year old, 6’1’ 200+ lb. soo was prescribed 5000 IU vitamin D3 for his winter depression (SAD). This fall he was noticably obese and the doctor said to take 10,000 IU of D daily. I was told Dec. a year ago my blood D level was 66 ngm/mL, a good level. This Dec. I asked for the test again and it was measured with p something not n. I have never seen this p measure in the Vit. D science articles. Also my numbers were very different. Anybody know anything about this p measurement
A year ago I had a restaurant dinner with 11 other vaccinated people. We sanitized our hands before passing platters of various Chinese dishes. Of course no masks while eating. Ten days later my nose started running like a faucet. Real thin clear mucus, unlike any other runny nose. I took 1 or 2 grams of Vitamin C every 2 or 3 hours even during the night to slow the drip. The next morning I woke with no runny nose and felt fine. Total 12 to 14 grams of C in 24 hours. Normally I take between 4 and 7 grams a day of C for allergies.
visceral fat around the organs of the body is not neutral. its inflammatory. that means that the body has to use up its glutathione to hold the inflammation at bay. that reduction in glutathione reduces the body’s ability to use vitamin d.
there for people with high bmi lose their ability to use vitamin d.
solution? raise glutathione levels. (a lot of ways to do that but glycine and nac are most popular.
My normal daily vitamin C is 1000 mg morning and evening. I add a 1,000 mg Chaga (mushroom) tablet at bedtime. The Chaga improves my sleeping SPO2% as measured by the Fitbit Charge4. On January 8th, my overnight states went to hell. Breathing rate hit 25 (normal 18), heart rate variability dropped to 8ms (normal 16), skin temperature +3.5F above baseline, SP02% 86 (normal 92 to 96). Nothing unusual in the rest heart rate stats. I had a strong positive COVID RAT that day as well. All stats back to normal now. Negative RAT.
Thanks for the report on vitamin C. I'll punch it up next time. I'm adding more NAC and bromelain right now to scrub any spike protein left over.
You used several terms or initials that I am not sure I understand. BA.1, SP02% (I think that is oxygen, but what is SP), Fitbit Charge4 (my partner has a little thing to test his O2%, is that it?), RAT.
I normally take 2 g. C with morning supplements and breakfast, and 2g. 12 hours later with a light snack. During the day I take 1 or 2 g. as needed. Stuffy nose, airborne molds, house dust, cigarette smoke allergies. Always need when cleaning up house (stirring up dust).
My partner has had a persistent cough. He has finally decided to take what I give him which this week included NAC. And starting 2 days ago I added and will continue with Quercetin and extra zinc, as well as the NAC to all the other items. He took his 2nd booster before X-mas, I could not talk him out of it. In the weeks before and the week after he had several episodes of tackycardia. I finally persuaded him that he needs to take extra magnesium to balance the Mylanta he is taking for GERD. (Any good thoughts on GERD?) No episodes since then but he is scheduled for Ablation surgery Feb. 10. and asked me to come with him Feb. 1 to talk with cardiologist. I am trying to decide what questions to ask and how unorthodox to risk.
I have been reading science papers on IgG4, and will send you the comment I made at another site. I was surprised there is a syndrome called IgG4RR, and one place is asking for volunteers with this to be studied. I also had a thought my partner might have a very small embolism in his lungs causing the persistent cough. Is this possible. Should I ask the doctor to give him a d-dimmer test? His prostate cancer after six months of anti-testosterone and 6 weeks radiation now gives a PSA of 0.03.
Two things of general interest I have done are give him 10 mg. of Astaxanthin for several months after I read that it seems to cause more apoptosis (normal cell death) in cancer tissue, and reduce the rate in normal tissue. I also gave him more zinc and Quercetin as I read a paper in which nine different cancers all had low zinc in the cancer tissue, even when the surrounding normal tissue had good or better zinc levels.
SP02% is a measure of oxygen saturation of the blood. A finger pulse oximeter is the best tool. Middle or ring finger. Above 96% is considered good. Under 92% is cause for concern. My sister (RN) had patients wandering around waiting rooms with an 80% SPO2. That is teetering on doing brain damage. The Fitbit is measuring off blood vessels in the wrist. Numbers are consistently lower than a finger pulse-ox device. Best I've ever achieved is 96% on the wrist. That 86% on January 8th was my worst ever.
Recent papers on IgG showed "class switching" after the 2nd mRNA vaxx. The normal neutralizing IgG3 dropped hard and the tolerating IgG4 appeared in large volumes. The interpretation is that the immune system switched to "tolerating" rather than trying to clear the spike protein.
Not trying to 2nd guess the cardiologist, but the ablation surgery is just hiding the root cause. Joel Wallach makes frequent appearances on CoastToCoastAM where he recommends specific supplements to fixed the pinched nerves in the spine/skull causing the heart issue. The supplements help the disks recover and remove the pressure on the nerves. A lot less invasive than an ablation surgery.
“glycine and nac are most popular.”
In other words, GlyNAC. I actually take them separately, and recently switched from glycine capsules to the glycine included in collagen capsules. The separate glycine was resulting in heartburn (happens to a few of us). GlyNAC in whatever form has substantial benefit at cellular level.
My partner (age 78) has the finger O2% device, from heart doctor. Last fall after babysitting his little grandson, too sick to go to preschool, he developed a bad sore throat and other symptoms and 3 weeks sick. Although I had started masking around him and taking Quercetin and extra zinc, I had symptoms too. Mostly it was a tightness across the back of the throat, felt almost like a bar there when I swallowed. I also could not take a deep breath, like my diaphragm could not lower with a breath. My 02% was 92. I also lacked energy (age 84). A few days later the throat and deep breath were normal. 02% ranged from 96 to 98, better energy. I don’t know if it was a bad cold or Covid, but it was much milder for me. No sore throat or cough.
He was babysitting again recently and now has a persistent cough. I am adding NAC, Quercetin and extra zinc to his usual supplements, starting 3 days ago. He takes them with breakfast but refused my suggestion he take some at bedtime when he does take his Flomax, and Mylanta and magnesium if his GERD is active. Last night I heard him coughing, not much during the day. I am wondering if he could have a tiny lung embolism. Should he get a d-dimer test?
I am still not exactly clear on the interaction of the mRNA vaccines (he had Moderna and 2 boosters), spike protein activity, and the influence of increased IgG4, which I already understand increase more with each booster. Could you explain this with simplicity a bright 10 year old could grasp, or a tired 84 year old?
He does have a visible bulge in the middle of his spine he says is spinal arthritis. More in a PM. Thanks for your interest and help.
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