Researchers identify three intestinal bacteria found in dementia with Lewy bodies (Bifidobacterium, Ruminococcus torques, & Collinsella help)

Medical Xpress / Nagoya University / npj Parkinson's Disease ^ | March 1, 2023 | Hiroshi Nishiwaki et al

[ConservativeMind]

Dementia with Lewy bodies (DLB), one of the most common forms of dementia, has no cure. Now, a group has identified three bacteria involved in DLB—Collinsella, Ruminococcus, and Bifidobacterium. Their findings suggest new avenues for diagnosis and treatment.

The onset of DLB is associated with abnormal deposits of alpha-synuclein, a protein in the brain.

A research group discovered that three intestinal bacteria, Collinsella, Ruminococcus, and Bifidobacterium, were associated with patients with DLB.

The bacteria Akkermansia, which degrades the intestinal mucosa, increased. On the other hand, the bacteria that produce short-chain fatty acids (SCFA) in the gut decreased.

On the other hand, the researchers found an increase in Ruminococcus torques, an increase in Collinsella, and a decrease in Bifidobacterium.

Importantly, the reduced levels of Bifidobacterium may also suggest possible ways to treat DLB. Bifidobacterium increases brain-derived neurotrophic factor, a key protein that supports the growth, development and maintenance of neurons in the central and peripheral nervous systems. Therefore, its decrease in DLB is likely to be associated with cognitive decline.

Similarly, both Ruminococcus torques and Collinsella are intestinal bacteria that carry an enzyme, the product of which regulates inflammation in a region of the brain called the substantia nigra. The substantia nigra produces dopamine, a neurotransmitter that is involved in the regulation of movement and is deficient in Parkinson's disease. Compared to Parkinson's disease, the levels of these bacteria were higher in people with DLB. This may explain why the effect on movement is delayed, a key feature that distinguishes DLB from Parkinson's disease.

"In terms of treatment, the administration of Ruminococcus torques and Collinsella in patients with Parkinson's is expected to delay neuroinflammation in the substantia nigra," Ohno added. "Therapeutic intervention to increase Bifidobacterium may delay the onset and progression of DLB and reduce cognitive dysfunction."

[ConservativeMind]

It’s pretty easy to find probiotic supplements with various bifidobacterium in them, but an apparent way to increase Ruminococcus torques is through supplementing two other types of probiotic families: Lactobacillus acidophilus and Bifidobacterium longum, along with eating more resistant starches (apparently Type II and Type IV), from an intriguing source for a malady that needs the opposite of what this disease needs, which I’ll post next.

[pangaea6]

It always seems to be about the gut and microbiome health

[ConservativeMind]

“Reducing Ruminococcus Genus,” from CFS Remission:

https://cfsremission.com/2017/10/18/reducing-ruminococcus-genus/

I haven't followed through on the study links, but Chronic Fatigue Syndrome appears to have a need for the opposite gut bacteria, it would seem.

[ConservativeMind]

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[FreedomPoster]

Which seems to be something most docs know little about, really.

[Faith65]

Thanks.
BKMK

[FrankRizzo890]

Soo, the cure for this is a nice big glass of water from downtown Manila?

That should pretty much clean you COMPLETELY out.

(I had some ice by accident in central Philippines a few years ago, and I was CLEAN, I’m talking SQUEAKY clean after about 48 hours).

[MomwithHope]

I would think ivermectin would help.