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Posted on 05/01/2023 3:44:51 PM PDT by ConservativeMind
Having that second cup may actually be good for coffee drinkers, according to a discussion of coffee's preventive and therapeutic benefits to human health in a recent review.
Research showed the mechanisms of action of coffee are complex and dependent on the effects of its constituents, including chlorogenic acids, polyphenolics, terpenoids, alkaloids and other phytochemicals.
"We also found evidence that the antioxidant activity of coffee, which activates the nuclear factor erythroid 2-related factor 2, or Nrf2, may be an important mechanism of action," Davidson said.
They found evidence protective effects of coffee in the gut decreased colon cancer risk, which may be due to its activity as an aryl hydrocarbon ligand. The aryl hydrocarbon receptor, AhR, is a transcription factor that regulates gene expression.
The study also demonstrated that roasted coffee-derived extracts function in part by activating the AhR. Coffee induced several AhR-dependent responses in the intestine. These included gene expression, inhibition of intestinal stem cell-enriched organoid growth and inhibition of intestinal barrier damage.
Their research also found that some coffee components bind the orphan nuclear receptor NR4A1 to the interactions with the AhR receptor. The NH4A1 receptor is a key factor in multiple diseases, such as arthritis, inflammation, cancer and cardiovascular diseases, and a high NR4A1 expression is associated with breast cancer.
The paper also refers to research focused on developing and discovering compounds for mechanism-based drug development to target both cancer and non-cancer endpoints.
"A major target for cancer chemotherapy includes specific protein transcription factors, the aryl hydrocarbon receptor, the estrogen receptor and orphan nuclear receptors NR4A1," Safe said.
Research has included collaboration to investigate the role of the aryl hydrocarbon ligand and its microbial metabolites on intestinal function and disease.
"We also have ongoing collaborations focused on endometriosis, Parkinson's Disease, and learning and memory," Safe said.
(Excerpt) Read more at medicalxpress.com ...
I always told people my cup of black coffee activated my nuclear factor erythroid 2-related factor 2, but would they listen? Nooooo….
Given what we know about who pays for various studies, should I ask if big coffee paid for this?
I’m glad to learn that all my receptors are wired together.
In fact I think I’ll have another cup.
bkmk
First it’s good, then it’s bad, then it’s good, then it’s bad...make up your minds “experts.”
Now that it’s baseball season, I’ve been drinking my morning coffee in my Chicago Cubs World Series mug.
It hasn’t been helping them…..
Roast, rest and grind your beans at home...you’ll never look at the overpriced stale crap in the stores again.
Bottom line...there is nothing on earth that you should eat...except rabbit food...alas...we're not rabbits.
Can't they just leave us alone...and stop with the crap school lunches.
I appreciate these posts. I learn a lot. And I love my morning coffee.
But here’s the way it usually goes:
Study #1: Coffee is good for you.
Study #2: No. Coffee is bad for you.
Study #3: No. Coffee is good for you.
Study #4: No. Coffee is bad for you.
Etc.
Sometimes I wonder if these guys question the current wisdom just to get published.
I’d like to say more, but it’s coffee time. It’s after 3 PM, so decaf only.
3 cups/day (minimum). Strong. Black.
“First it’s good, then it’s bad, then it’s good, then it’s bad...make up your minds “experts.”
Exactly what I was thinking. Wait till next week.
bttt
I drink two cups of strong coffee with heavy whipping cream daily....I am a firm believer it is GOOD for me!!...
Given what we know about who pays for various studies, should I ask if big coffee paid for this?
My reaction is a little different.
My first thought is of the experts who a few years ago insisted that it would kill you.
I think they were the same ones that told us that they knew all about the dangers of cholesterol.
I wonder what mavels they will have for us next?
I typically drink coffee “black as midnight on a moonless night,” to quote David Lynch (I think).
But occasionally I mix a cup into a vanilla milkshake. Damn, that tastes good.
I roast in a good stove top popcorn popper. What’s your roasting technique?
Now that I no longer work, I’m drinking 4-5 cups daily. In a large mug. But, I’m buying the cheap stuff since the crappy brands now cost so much! Hope I’m healthy.
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