Molecular trigger for breast cancer development identified (Tamoxifen can prevent breast cancer)

Medical Xpress / Harvard Medical School / Nature ^ | May 17, 2023 | Peter Park et al

[ConservativeMind]

In what may turn out to be a long-missing piece in the puzzle of breast cancer, researchers have identified the molecular sparkplug that ignites cases of the disease currently unexplained by the classical model of breast-cancer development.

"We have identified what we believe is the original molecular trigger that initiates a cascade culminating in breast tumor development in a subset of breast cancers that are driven by estrogen," said Peter Park.

The researchers said as many as one-third of breast cancer cases may arise through the newly identified mechanism.

The study also shows that the sex hormone estrogen is the culprit behind this molecular dysfunction because it directly alters a cell's DNA.

"Our work demonstrates that estrogen can directly induce genomic rearrangements that lead to cancer, so its role in breast cancer development is both that of a catalyst and a cause," said Jake Lee.

Estrogen receptors are known to bind to certain regions of the genome when a cell is stimulated by estrogen. The researchers found that these estrogen-binding sites were frequently next to the zones where the early DNA breaks took place.

Estrogen is already known to fuel breast cancer growth by promoting the proliferation of breast cells. However, the new observations cast this hormone in a different light.

They show estrogen is a more central character in cancer genesis because it directly alters how cells repair their DNA.

The findings suggest that estrogen-suppressing drugs such as tamoxifen—often given to patients with breast cancer to prevent disease recurrence—work in a more direct manner than simply reducing breast cell proliferation.

"In light of our results, we propose that these drugs may also prevent estrogen from initiating cancer-causing genomic rearrangements in the cells, in addition to suppressing mammary cell proliferation," Lee said.

[ConservativeMind]

Tamoxifen appears capable of directly preventing breast cancer, before it ever starts.

This is available today, for under $10, from some pharmacies.

[ConservativeMind]

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[LTC.Ret]

Random search cancer research website:
“However, tamoxifen is not without risk. The most serious adverse side effects of tamoxifen are blood clots and endometrial cancer. Tamoxifen also can affect quality of life as some women experience menopause-like symptoms such as hot flashes and difficulty with intercourse. Due to these lifestyle side effects, there is a significant percent of patients who stop tamoxifen therapy despite known benefits.
One recent study revealed 21% of women stopped their therapy within a year of diagnosis and 35% stopped by 3.5 years.”

Tamoxifen has been researched and available for years. This is not a new drug. Read and listen carefully before taking ANY drug, especially if there are new or updated drugs on the market with fewer side effects and/or if the drug is being actively pushed in advertising.

[Jane Long]

I wonder if there is a natural form of tamoxifen.

A childhood friend’s mother had breast cancer....decades ago...and, was put on a daily, perpetual dose of tamoxifen. She lived for another three decades....with no cancer reoccurrence.

She died of old age/natural cause.

[windcliff]

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