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Chemical found in common sweetener damages DNA (Sucralose)
Medical Xpress / N Carolina St Univ / Journal of Toxicology and Environmental Health, Part B ^ | May 31, 2023 | Matt Shipman / Susan S. Schiffman et al

Posted on 06/02/2023 6:40:06 AM PDT by ConservativeMind

A new study finds a chemical formed when we digest a widely used sweetener is "genotoxic," meaning it breaks up DNA. The chemical is also found in trace amounts in the sweetener itself, and the finding raises questions about how the sweetener may contribute to health problems.

At issue is sucralose, a widely used artificial sweetener sold under the trade name Splenda. Previous work by the same research team established that several fat-soluble compounds are produced in the gut after sucralose ingestion. One of these compounds is sucralose-6-acetate.

"To put this in context, the European Food Safety Authority has a threshold of toxicological concern for all genotoxic substances of 0.15 micrograms per person per day," Schiffman says. "Our work suggests that the trace amounts of sucralose-6-acetate in a single, daily sucralose-sweetened drink exceed that threshold. And that's not even accounting for the amount of sucralose-6-acetate produced as metabolites after people consume sucralose."

For the study, researchers conducted a series of in vitro experiments exposing human blood cells to sucralose-6-acetate and monitoring for markers of genotoxicity.

"In short, we found that sucralose-6-acetate is genotoxic, and that it effectively broke up DNA in cells that were exposed to the chemical," Schiffman says.

Schiffman says: "When we exposed sucralose and sucralose-6-acetate to gut epithelial tissues—the tissue that lines your gut wall—we found that both chemicals cause 'leaky gut.' Basically, they make the wall of the gut more permeable. The chemicals damage the 'tight junctions,' or interfaces, where cells in the gut wall connect to each other.

"We found that gut cells exposed to sucralose-6-acetate had increased activity in genes related to oxidative stress, inflammation and carcinogenicity," Schiffman says.

"If nothing else, I encourage people to avoid products containing sucralose. It's something you should not be eating."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: espionage; schiffman; splenda; sucralose; susan; susansschiffman
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To be fair, many compounds are genotoxic to some extent, but this appears to be both common and above new limits set in Europe.
1 posted on 06/02/2023 6:40:07 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 06/02/2023 6:40:38 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

After T2 diabetes diagnosis, I swichted to splenda, then truvia. Heck...reports like this made me go from 3/4 coffee, 1/4 whole milk. Still sweet to me w/o the blood sugar issues.


3 posted on 06/02/2023 6:47:37 AM PDT by DCBryan1 (Das dicke Ende kommt noc!)
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To: ConservativeMind

Mmmm.....chlorinated hydrocarbon, just like DDT. You can destroy fire ant mounds with sucralose.

4 posted on 06/02/2023 6:49:52 AM PDT by Overtaxed (Templum meum in corde meo et mente mea est.)
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To: ConservativeMind

Have to compare it with the effects of corn sweeteners. Using splenda definitely reduces my blood glucose.


5 posted on 06/02/2023 6:50:38 AM PDT by Larry Lucido (Donate! Don't just post clickbait!)
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To: ConservativeMind

I was a Splenda junkie for a few years...gave up most of it when I stopped drinking diet soda and gave up the rest when I started caring about my microbiome. Nevertheless, as this is a headline-making “discovery”, we should be asking who funded the study? Big Sugar has lost a lot of business to Splenda.


6 posted on 06/02/2023 7:00:24 AM PDT by LizzieD
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To: DCBryan1

I like coffee with condensed milk in it. Not sure what sugar is I. Condensed milk if any, but it adds just a touch of sweetness to coffee which I drink cold now.


7 posted on 06/02/2023 7:00:54 AM PDT by Bob434 (question )
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To: DCBryan1

Ok just looked up condensed milk... ugggh, it’s 50% or more sugar lol.


8 posted on 06/02/2023 7:03:19 AM PDT by Bob434 (question )
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To: Bob434

The product you probably want is evaporated milk as it is not sugar-sweetened beyond the natural milk sugar/lactose.


9 posted on 06/02/2023 7:12:15 AM PDT by T-Bird45 (It feels like the seventies, and it shouldn't. )
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To: ConservativeMind

It's something you should not be eating.


10 posted on 06/02/2023 7:19:55 AM PDT by Delta 21 (MAGA Republican is my pronoun.)
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To: ConservativeMind

A link to the study...

https://www.tandfonline.com/doi/full/10.1080/10937404.2023.2213903


11 posted on 06/02/2023 7:23:13 AM PDT by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: Larry Lucido

All of the newly named sugars but not sugars go directly to your liver for processing. Just like with alcohol, the liver can handle about an ounce an hour. After that it gets stored away in the liver/pancreas as FAT to be processed later and your blood sugar is low and happy and you have cirrhosis of the liver or Non alcoholic liver disease.
The High Fructose Corn Syrup advocates never told anyone that, did they?


12 posted on 06/02/2023 7:23:22 AM PDT by Delta 21 (MAGA Republican is my pronoun.)
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To: T-Bird45

Thnaks- What I try to do is make like a cold cappuccino taste, which needs the sweetness, but just a little. I will try the evaporated with just a hint of sugar- the condensed seems like diabetes in a can now that i looked into the contents lol


13 posted on 06/02/2023 7:25:03 AM PDT by Bob434 (question )
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To: ConservativeMind
Maybe we shouldn't eat anything, it's what the WEF wants.

14 posted on 06/02/2023 7:28:11 AM PDT by BitWielder1 (I'd rather have Unequal Wealth than Equal Poverty.)
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To: DCBryan1

Diabetic for 25 years and counting. Tried every artificial sweetener known to man, can’t stand the taste, some give me nasty headaches. Been avoiding them for over 20 years. Call me Mr. Natural - I use honey if I use sweetener at all, which is not often.


15 posted on 06/02/2023 7:29:12 AM PDT by Chad C. Mulligan
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To: LizzieD
...we should be asking who funded the study? Big Sugar has lost a lot of business to Splenda.

Exactly. Medical studies, once respected and trusted, are now suspect, depending upon the funding source. Look what happened with all of the fake studies "proving" ivermectin and HCQ were either dangerous or useless against the Chinese virus. Many were later retracted (after the damage was done).

16 posted on 06/02/2023 7:32:07 AM PDT by Blennos
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To: ConservativeMind

I’ve been drinking diet colas- I guess I better re-think that…


17 posted on 06/02/2023 7:41:58 AM PDT by telescope115 (I NEED MY SPACE!!! 🔭)
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To: Delta 21

Another reason to get off the diet cola…


18 posted on 06/02/2023 7:44:10 AM PDT by telescope115 (I NEED MY SPACE!!! 🔭)
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To: ConservativeMind

Well, this is new.

But it doesn’t matter, especially if one reading this understands why it doesn’t matter (Capt. Obvious).


19 posted on 06/02/2023 8:01:36 AM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: Blennos
From Calorie Control Council Statement on Schiffman Sucralose Review:

A new review from Schiffman and Rother1 on biological issues related to sucralose is an opinion piece that reiterates past opinions expressed by Schiffman that have been previously refuted by experts in safety assessment. The publication represents no additional research and does not consider the vast evidence on sucralose which concludes that it is safe and can also be an effective tool in weight and diabetes management in humans.

Schiffman previously wrote a low-fat/high carb cookbook for the Nutrisystem diet, and has been a one-woman Cassandra against sucralose for a long time. While sucralose has problems, all the current sweetener alternatives are demonstrably worse by a long shot.

20 posted on 06/02/2023 8:13:44 AM PDT by Reeses
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