Posted on 06/21/2023 5:37:18 PM PDT by ConservativeMind
Precision medicine seeks to adapt treatments to the characteristics of each patient. Genome studies are providing more and more data to achieve this, but this very abundance of information is hampering the task: Doctors must interpret numerous genetic alterations, and only a few will be relevant to diagnose the type and stage of each cancer and decide how to treat it.
To facilitate this task, the National Cancer Research Centre (CNIO) launched the PanDrugs2 software program, which generates reports to facilitate clinical decisions.
PanDrugs2 analyzes the genomic data of each patient in search of molecular targets, in other words molecules on which existing drugs act.
Altogether, the platform handles data on 4,642 genes and 14,659 unique chemical compounds. Based on that information, it has generated 74,000 associations between drugs and genes.
Approved, experimental and trial drugs
PanDrugs2 improves on the previous PanDrugs platform, published five years ago. For example, it is the first platform that takes into account inherited (or germinal) mutations, in addition to those originated after conception (or somatic).
As for information regarding drugs, PanDrugs2 classifies them according to the type of disease for which they are indicated, the resistance they may generate; or the clinical phase in which they are: In trial, US approved, EU approved, experimental treatments, etc.
Open source, easy to update and with more scientific evidence
The program is free and open source. Given its tremendous utility in research, it offers two modes of consultation: clinical, aimed at medical professionals, which includes in its results approved and / or clinical trial drugs; and discovery mode, aimed at scientists, which takes into account direct therapeutic targets [mutated genes] and indirect ones [other genes that are also involved in the development of the disease], and also includes experimental treatments.
(Excerpt) Read more at medicalxpress.com ...
Give this to your oncologist, if they don’t have something this useful.
You could even play with it, yourself, it would appear.
Wouldn’t this software and technique have been useful when COVID started? Was something like this shut down by Big Pharma?
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