Posted on 06/23/2023 1:25:51 PM PDT by ConservativeMind
In a study, researchers revealed that carrying excess belly fat is related to greater inflammation and mortality in COVID-19 patients.
"While treating patients with COVID-19, we noticed that obese patients with predominantly abdominal fat tended to experience more severe disease courses and worse outcomes (A, B)," says Tadashi Hosoya.
To test this, the researchers used two types of obese mice: ob/ob mice, which are susceptible to putting on abdominal fat, and db/db mice, which put on fat all over. Leptin signaling, which regulates appetite, is impaired in both types of mice, leading them to become obese from overeating. These two types of obese mice and non-obese control mice were then infected with mouse-adapted SARS-CoV-2, and the researchers monitored the mice for outcomes such as inflammation, lung injury, and death.
"The results were very striking," explains Shinsuke Yasuda, senior author. "The ob/ob mice all died after infection with SARS-CoV-2, while most of the non-obese control mice and even the obese db/db mice survived (C)."
They noted that ob/ob mice produced more pro-inflammatory factors than db/db mice. Importantly, blocking one in particular, interleukin-6 (IL-6), partially but significantly improved survival rates in these obese mice.
Of note, "lean" ob/ob mice can be generated by giving them a preventive leptin supplement, and they survived SARS-CoV-2 infection more often than their obese counterparts. However, giving the leptin supplement after the mice had already become obese did not help them survive the infection (D).
"Our findings suggest that excessive adipose tissue is related to activation of cytokine storm and delayed elimination of SARS-CoV-2, thus predicting mortality," says Seiya Oba.
Given that anti-inflammatory therapies, including IL-6 blockers, are already available, these findings suggest that obese patients with excess belly fat would benefit most from this treatment strategy.
(Excerpt) Read more at medicalxpress.com ...
Not knocking the article exactly, but why are they still talking about COVID19?
Trying to fiercely fan the flames of fear.
Its the visceral fat around the organs and in the organs example: fatty liver disease ..—that are the source of a lot of the chronic diseases...because the visceral fat throws off a lot of inflammatory cytokines.
Are there any otc knockoffs of these drugs that you can take.
people should not be shaped like fruit.
it is disgusting.
I have an apple shape, but I identify as an inverted triangle.
Like the jelly apple on two sticks? Or the pear shaped one? Celery stalk, or cucumber is probably best shape.
not only shame people, but now shame where they are fat...
not only shame people, but now shame where they are fat...
FTR, I consider myself to be overweight, never had covid, never had the vaxx....infact, been sick with a head cold just once since Dec 2019.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.