Posted on 07/20/2023 3:23:19 PM PDT by ConservativeMind
Treatment for locally advanced cutaneous squamous cell cancers (laCSCC) remains poorly defined. Most laCSCC tumors express high levels of epidermal growth factor receptors (EGFR). Cetuximab has activity in other EGFR expressing cancers and enhances the effectiveness of radiotherapy.
In this new study, researchers conducted a retrospective review of institutional data and identified 18 patients with laCSCC treated with cetuximab induction and concurrent radiotherapy.
"We performed a retrospectively review of treatment outcome and toxicity in our patients who received concurrent cetuximab and radiotherapy to show an additional potentially effective treatment option for patients with laCSCC," say the researchers.
The loading dose of cetuximab was 400 mg/m² IV. Subsequent weekly doses of 250 mg/m² IV were infused throughout the period of radiation. The treatment doses ranged from 4,500–7,000 cGy, with a dose fraction of 200–250 cGy. The objective response rate was 83.2% with 55.5% complete responses and 27.7% partial responses.
Median progression-free survival was 21.6 months. Progression-free survival was 61% at one year and 40% at two years. With longer follow-up, some patients developed a local recurrence (16.7%), distant metastases (11.1%) or a second primary cancer (16.3%). Cetuximab was well tolerated, with 68.4% patients experienced only mild acneiform skin rash or fatigue (Grade 1 or 2). Radiotherapy produced expected side effects (skin erythema, moist desquamation, mucositis).
"Cetuximab plus radiotherapy represents an active and tolerable treatment option for laCSCC, including patients with contraindications for checkpoint inhibitor therapy," conclude the researchers.
(Excerpt) Read more at medicalxpress.com ...
It’s important we get ourselves checked for skin cancer, at least once a year, as we age. Someone in our lives can help identify unusual changes in places we can’t see, but absent that, it’s pretty awkward to self examine your own back, but you can use a camera.
Find a trustworthy dermatologist. You will need one, anyway, for handling the more common basal cell carcinomas we all seem to get.
Bookmark.
Recent reports out of India are claiming that the drug Dostarlimab/Jemperli is very good at curing any Stage 4 cancer completely.
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