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Results:ThespecificPP-pike fragment was found in 50% of the biological samples analyzed, and its presence was independent of the SARS-CoV-2IgG antibody titer. The minimum and maximum time at which PP-spike was detected after vaccination was 69 and 187days, respectively. Conclusions and clinical relevance:The presented method allows to evaluate the half-life of the Spike protein molecule “PP” and to consider the risks or benefits in continuing to administer additional booster doses of the SARS-CoV-2 mRNA vac-cine. This approach is of valuable support to complement antibody level monitoring and represents the first proteomic detection of recombinant Spike in vaccinated subjects. KEYWORDSC OVID-19, mass spectrometry, SARS-CoV-2, Spike protein,vaccine mRNA
I don’t see any conclusions in the Conclusions section.
Is this bad news?
Conclusions and clinical relevance:
The presented method allows to evaluate the half-life of the Spike protein molecule “PP” and to consider the risks or benefits in continuing to administer additional booster doses of the SARS-CoV-2 mRNA vaccine.
This approach is of valuable support to complement antibody level monitoring and represents the first proteomic detection of recombinant Spike in vaccinated subjects.