Posted on 09/20/2023 12:15:50 PM PDT by ConservativeMind
In a new study, researchers found that patients prescribed amoxicillin-clavulanate had higher rates of gastrointestinal symptoms and yeast infections than those prescribed amoxicillin.
Acute sinusitis is one of the most common causes for children to be put on antibiotic medications.
Scientists analyzed the treatment outcomes of over 300,000 children who were prescribed either of the two drugs. They found that there was no difference in the rates of treatment failure between patients prescribed amoxicillin and amoxicillin-clavulanate.
Treatment failure was so rare that the study's authors say that physicians should be confident that either medication will clear a case of acute sinusitis that requires antibiotics. But the risk of adverse events, especially gastrointestinal symptoms and yeast infections, were higher among those prescribed amoxicillin-clavulanate.
Amoxicillin-clavulanate is believed to treat a wider range of bacteria than amoxicillin.
The researchers pulled data from 320,141 clinical cases of children. They discovered that there was no difference in the rates of treatment failures associated with either medication.
Treatment failure in general was exceedingly rare; less than 2% of prescriptions failed, most of which were corrected by an outpatient medication change. Only 0.1% of children had failures so severe that they required a visit to the emergency room or hospitalization.
The clinical data showed that adverse events were somewhat rare but more frequent among patients treated with amoxicillin-clavulanate, occurring in 2.3% of patients treated with amoxicillin-clavulanate and 2% of patients treated with amoxicillin. Patients treated with amoxicillin-clavulanate had a 15% increased risk of gastrointestinal side effects and 33% higher risk of yeast infections compared to patients treated with amoxicillin.
As this was not a randomized clinical trial, the study authors also acknowledge the possibility that residual bias could have impacted the results, although they re-analyzed the data several different ways with no difference in the results.
(Excerpt) Read more at medicalxpress.com ...
I found out the hard way that clavulanate gave me severe rashes.
amoxicillin-clavulanate - no bueno.
Vicious nausea and stomach pains - won’t touch that stuff ever again.
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