Trigonelline derived from coffee improves cognitive function, shows potential in alleviating age-related impairment

Medical Xpress / University of Tsukuba / GeroScience ^ | Sept. 21, 2023 | Sharmin Aktar et al

[ConservativeMind]

The search for functional natural compounds that can improve age-related cognitive decline has recently emerged as an important research focus to promote healthy aging.

Trigonelline (TG), a plant alkaloid found in coffee, as well as in fenugreek seed and radish, was anticipated to possess cognitive enhancement properties.

In a study, researchers investigated the effects of TG on memory and spatial learning (acquiring, retaining, structuring, and applying information related to the surrounding physical environment) from both a cognitive and molecular biology perspective in an integrated manner using a senescence-accelerated mouse prone 8 (SAMP8) model.

Following oral administration of TG to SAMP8 mice for 30 days, the Morris water maze test indicated a significant improvement in spatial learning and memory performance compared with SAMP8 mice that did not receive TG.

Next, the researchers performed whole-genome transcriptomic analysis of the hippocampus to explore the underlying molecular mechanisms. They found that signaling pathways related to nervous system development, mitochondrial function, ATP synthesis, inflammation, autophagy, and neurotransmitter release were significantly modulated in the TG group.

Furthermore, the research team found that TG suppressed neuroinflammation by negatively regulating signaling factor Traf6-mediated activation of the transcription factor NF-κB.

Additionally, quantitative protein analysis confirmed that the levels of inflammatory cytokines TNF-α and IL-6 were significantly decreased and the levels of neurotransmitters dopamine, noradrenaline, and serotonin were significantly increased in the hippocampus.

These findings suggest the efficacy of TG in preventing and improving age-related spatial learning memory impairment.

[ConservativeMind]

From Wikipedia:

“Trigonelline occurs in many plants. It has been isolated from the Japanese radish (Raphanus sativus cv. Sakurajima Daikon), fenugreek seeds, garden peas, hemp seed, oats, potatoes. Trigonelline is also found in coffee. Higher levels of trigonelline are found in arabica coffee.”

[ConservativeMind]

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[Bob434]

[[They found that signaling pathways related to nervous system development, mitochondrial function, ATP synthesis, inflammation, autophagy, and neurotransmitter release were significantly modulated in the TG group. ]]

I guess we are to assume they were all “modulated in a positive manner”?

[ProtectOurFreedom]

I derive my Trigonelline every morning.

[Zionist Conspirator]

[Bounced2X]

I derive my Trigonelline every morning.

I just got done consuming a 1/2 a pot of it.
I'll have the Theory of Everything ready for posting by dinner time. ;O)

[Grampa Dave]

“I derive my Trigonelline every morning.”

So do my wife and I!”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146819/table/molecules-28-03460-t003/

[Noumenon]

Coffeeeeeeeeeee!

[ProtectOurFreedom]

Table 3

Theoretical maximum daily intake of trigonelline via coffee and coffee by-products, (g/day)

Coffee beverages 13.8

---

What?? A THEORETICAL maximum daily intake? What in the world are they talking about?

[irishjuggler]

Well, it is possible to overdose on caffeine and have a stroke, heart attack etc. It’s apparently happened to people consuming caffeine pills or powder. If you guzzled 14 cups of joe within the space of a couple hours, would you be close to that toxic level of caffeine? Maybe, but I suspect anyone guzzling that much coffee would suffer an upset stomach before they got into such dangerous territory.

[Grampa Dave]

Probably based on rat or mouse doseage/intake. These people think differently, speak differently and make oral/written citations different from the rest of us!:

1 For coffee by-products, a preparation of tea infusions with 2 g of coffee by-product per 200 mL of cold water was assumed. For further explanation, see text. For coffee beverages, the assumption of weighing-in 2 g of, in this case, ground, roasted coffee beans, was not made as data for the final beverage are available (see Table 2). To account for the outlined worst-case scenario, for each matrix the highest trigonelline content as reported in Table

2 was used in the calculations.

[PLMerite]

“Trigonelline”

I thought it was some new kind of math, but it’s just coffee.

[ProtectOurFreedom]

I was writing with tongue firmly in cheek. A cup of decaf and a cuppa regular is all I can take and it has to be early in the morning. Any more than that and I'll wake at 2 am and that's it for the night.

I've taken up a new hobby -- collecting coffee beans from local roasters in our travels. I just picked up beans from roasters in Winthrop, WA; Whistler, BC; Revelstoke, BC; and Banff, AB (actually roasted in Calgary). I just had a cup of "Soledad" roasted by Good Earth in Calgary. It was really good - "Dark roast Guatemala, Brazil & Latin America."

It's a cheap, simple, and rewarding hobby. Plus, I get to renew my coffee supply as it runs out. It's an excuse for another trip!

My other cheap hobby is collecting baseball caps from our travels. I just got two from Jasper, AB. One is from Lake Maligne where we went canoeing in a stiff breeze...

We hit absolutely perfect late-summer / early fall weather before the snow flies. The tour boats were sold out, so we decided to go out in the canoe and I'm really glad we did. That was a LOT better than being on a powered cruise boat with endless narration for 90 minutes.

How's that for a seamless segue from trigonelline to a travelogue!?

[null and void]

(I have the shirt)

[Terry L Smith]

I will stay with my 3 cups a day, thanks.

[ProtectOurFreedom]

LOL...that’s hilarious.

[GaltAdonis]

- Kona Coffee from Hawaii! -

YES!

[Faith65]

Thanks.
bfl

[RouxStir]

I have my great-great grandfather’s biggin (old-style French coffee maker). If you haven’t had coffee made the old way in a biggin...you haven’t had coffee. He roasted coffee beans and ground them in his general store. The descendants continued roasting, grinding and selling coffee until some time between WWI and WWII. I’m not sure who wound up with the old coffee grinder that was in the last general store. I remember seeing it attached to a wooden stand near where my grandfather would slice ham, bologna, cheese, salami, etc. They had to close the store when Interstate-10 was built and the property was “taken.” By that time, packaged ground coffee was most of the coffee business. I still use the biggin, once in a while...it’s a process that most people don’t have time for, today. With a biggin, you can make coffee that makes the hairs on your arm stand up when you take a sip. My grandfather started giving us coffee when we were about 2 years old...black as asphalt, with a rainbow of oil on top from the beans, until we added the sweetened condensed milk...then we had plenty of energy to run around playing for hours.

In fact, I think I need to start a pot of coffee in the biggin right now.

[Red Badger]

This week, COFFEE GOOD.

Next week, COFFEE BAD........................