Study finds natural molecule in coffee and human body increases NAD+ levels, improves muscle function during aging (Trigonelline from coffee & fenugreek increases NAD+)

Medical Xpress / National University of Singapore / Nature Metabolism ^ | March 21, 2024 | Mathieu Membrez et al

[ConservativeMind]

A research consortium led by Nestlé Research in Switzerland made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function.

The work builds on a previous collaborative study that described novel mechanisms of human sarcopenia.

Sarcopenia is a condition where cellular changes that happen during aging gradually weaken the muscles in the body and lead to accelerated loss of muscle mass and strength and reduced physical independence.

One important problem during sarcopenia is that the cellular cofactor NAD+ declines during aging, while mitochondria, the energy powerhouses in our cells, produce less energy. The study team discovered that levels of trigonelline were lower in older people with sarcopenia.

Providing this molecule in pre-clinical models resulted in increased levels of NAD+, increased mitochondrial activity, and contributed to the maintenance of muscle function during aging.

NAD+ levels can be enhanced with different dietary precursors like the essential amino acid L-tryptophan (L-Trp), and vitamin B3 forms such as nicotinic acid (NA), nicotinamide (NAM), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

Assistant Professor Vincenzo Sorrentino added, "Our findings expand the current understanding of NAD+ metabolism with the discovery of trigonelline as a novel NAD+ precursor and increase the potential of establishing interventions with NAD+-producing vitamins for both healthy longevity and age-associated diseases applications."

[ConservativeMind]

A newly identified benefit from a natural compound can help improve muscle loss in older people.

Coffee and fenugreek are ways to get this, along with supplements of various type, mentioned above.

[Dr. Sivana]

I seem to remember that fenugreek is used to induce lactation.

[ConservativeMind]

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[Veto!]

Any particular kind of coffee? I would assume not instant coffee.

My cardiologist OK’d two cups of fresh ground half-caf for breakfast. “That equals one cup of coffee,” he said.

[Noumenon]

Coffeeeee! You can sleep when you’re dead.

[Adder]

the natural molecule trigonelline present in coffee
[Siiiiippppp] Good to know...but you had me at coffee.

[NewHampshireDuo]

I drink lots of coffee and my nads are fine.

[Red Badger]

At my age, I always need more NADs....................

[Red Badger]

My cardiologist said eat whatever you want, I’m not a nutritionist...............