I predict she will have some illness or become "first widow" in order to create shielding.
Remember the feminista outrage when Lazio "attacked" her with the dangerous piece of paper. (she may have gotten a paper cut!)
Symbolism over substance.
I'm still waiting for a medically-sound explanation for her "feign"ting bit last week. Imagine a US where "Her POTUSness" might collapse anytime the stresses of office become too great. This'd be a great tidbit to revisit if she decides to run.