Seems like every discipline has things which we can know, things which we do not yet know, and things which we can never know.
Concerning the unknowable - in mathematics, we have Gödel's Incompleteness Theorems. In physics, we have Heisenberg's Uncertainty Principle. And in the historical sciences - evolution, archeology, anthropology, Egyptology - we have an incomplete record of evidence.
To me, all of these are cautions which attach to the value of evidence and/or work product - but not to the value of the discipline itself.