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MMR Vaccine is Safe, International Team Affirms
MedPage Today ^ | 10/19/2005 | Neil Osterweil

Posted on 10/20/2005 4:50:24 AM PDT by Born Conservative

ALESSANDRIA, Italy, Oct. 19 - The only serious harm associated with the mumps-measles-rubella (MMR) vaccine is the risk to the health of children who aren't vaccinated, pronounced an international team of investigators today

"In particular we conclude that all the major unintended events, such as triggering Crohn's disease or autism, were suspected on the basis of unreliable evidence," said Vittorio Demicheli, M.D., of the Servizo Sovrazonale di Epidemiologia here and colleagues in a systematic review from the Cochrane Collaboration.

"Mumps, measles and rubella are serious diseases that can lead to potentially fatal illness, disability and death." Dr. Demicheli and colleagues wrote. "Measles, mumps and rubella are particularly prevalent in developing countries where vaccination programs are inconsistent and the mortality rate from disease is high. In developed countries, however, mumps, measles and rubella are now rare, due to large-scale vaccination programs."

Doubts about the safety of the MMR vaccine spring from a single study of 12 patients published by Andrew J. Wakefield, M.D., and colleagues in The Lancet in 1998. In that study, the authors reported that "onset of behavioral symptoms was associated, by the parents, with measles, mumps, and rubella vaccination in eight of the 12 children, with measles infection in one child, and otitis media in another."

The Wakefield paper also found an associated (sic) between MMR and gastrointestinal disease. The study was retracted in 2004 by 10 of the original 13 authors.

In the current review, Dr. Demicheli and colleagues conducted a systematic literature review looking for evidence of MMR vaccine effectiveness and adverse events associated with its use. They identified 139 studies, 31 of which were deemed to be of sufficiently high quality to rule out bias or error.

The studies included comparative prospective or retrospective trials testing the effects of MMR compared with placebo, no treatment, or to a combination of measles, mumps and rubella antigens on healthy children up to 15 years old.

The investigators found that the vaccine was associated with a lower rate of upper respiratory tract infections, higher rate of irritability, and similar rate of other adverse effects compared to placebo.

They also found positive associations between MMR and benign thrombocytopenic purpura, parotitis, joint and limb complaints, and febrile convulsions within two weeks of vaccination.

In addition, versions of the vaccine containing the Urabe strain of mumps, but not the more widely used Jeryl Lynn strain, were associated with aseptic meningitis.

In contrast, the reviewers found no credible evidence of an association between MMR vaccination and Crohn's disease, ulcerative colitis, or autism.

Although they were unable to identify MMR effectiveness studies with clear clinical endpoints, the overwhelming evidence of elimination or radical reduction of the targeted diseases via mass immunization campaigns stands as proof that the vaccine works as intended, they wrote.

"The safety record of MMR is possibly best attested by its almost universal use," Dr. Demicheli and colleagues wrote. "Its evaluation cannot be divorced from its effectiveness and the importance of the target diseases. As such, MMR remains an important preventive global intervention." Primary source: Cochrane Library
Source reference:
Demicheli V et al. Vaccines for measles, mumps and rubella in children (Review). The Cochrane Library 2005, Issue 4.

Additional source:
The Lancet
Source reference:
Wakefield AJ et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998. 28;351(9103):637-41.



TOPICS: Culture/Society; Extended News
KEYWORDS: autism; health; medicine; mmr; wakefield
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1 posted on 10/20/2005 4:50:25 AM PDT by Born Conservative
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To: Born Conservative

Chiropractors do much to advance this misconception on vaccination of children. They want to advice their own practice and belief that ALL diseases can be cured by "spinal manipulation". ALL diseases can be cured by a chiropractic "adjustment".

Anyone who believes these quacks are putting their children at serious and high risk.


2 posted on 10/20/2005 5:07:44 AM PDT by micho
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To: Born Conservative

This seems like junk science to me. When does anyone ever retract a earlier study unless they were intimidated? Revise and extend maybe, but retract?

The have been other studies with other vaccines and murine models that identify the sub-genetic markers that are suseptable to the vaccine.

We even have an example in humans with the lyme disease vaccine.

Too bad they wont take the research to find the real answer.


3 posted on 10/20/2005 5:11:13 AM PDT by fooman (Get real with Kim Jung Mentally Ill about proliferation)
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To: micho

There are some things that a chiropractor is good for, but when they start talking about curing various diseases with spinal manipulation, that is pure quackery. Also, I would NEVER have my neck manipulated. One of my co-workers was a nurse on a Neuro floor, and she took care of several patients who STROKED after having their necks manipulated.


4 posted on 10/20/2005 5:14:08 AM PDT by Born Conservative (Don't take your organs to Heaven. Heaven knows we can use them here.)
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To: fooman

Intimidated??? They are quaking in their boots. The whole Vaccine Conspiracy is about to be blown right out of the water, and they are scrambling to cover their behinds...

Check out this testimony by Rep Dan Burton....

http://autism.about.com/library/weekly/aa070902d.htm

Committee on Government Reform
"The Status of Research into Vaccine Safety and Autism"
June 19, 2002
2154 Rayburn House Office Building
11:00 a.m.
In April the Committee conducted a hearing reviewing the epidemic of autism and the Department of Health and Human Service's (HHS) response. Ten years ago, autism was thought to affect 1 in 10,000 individuals in the United States. When the Committee began its oversight investigation in 1999, autism was thought to affect 1 in 500 children. Today, the National Institutes of Health (NIH) estimates that autism affects 1 in 250 children.

In April we looked at the investment our Government has made into autism as compared to other epidemics. We showed in that hearing that the CDC and NIH have not provided adequate funding to address the issues in the manner that our Public Health Service agencies have used to address other epidemics.

After our hearing, I joined with my colleagues on the Coalition on Autism Research and Education to request from our appropriators that at least 120 million dollars be made available in FY 2003 for autism research across the NIH and at that an additional $8 million be added to the CDC's budget for autism research.

Giving more money to research is not the only answer though. Oversight is needed to make sure that research that is funded will sufficiently answer the questions regarding the epidemic, how to treat autism, and how to prevent the next ten years from seeing the statistic of 1 in 250 from becoming 1 in 25 children.

High quality clinical and laboratory research is needed now, not five or ten years from now. Independent analysis of previous epidemiological and case control studies is needed as well.

We have learned that a majority of parents whose children have late-onset or acquired autism believe it is vaccine-related. They deserve answers. We have also learned that the parents have been our best investigators in looking for both causes of autism and for treatments.

It has been parents who have formed non-profit organizations to raise research dollars to conduct the research that the CDC, the FDA, and the NIH have neglected to do. We have heard from many of these parents in the past, Elizabeth Birt, Rick Rollens, Shelley Reynolds, and Jeanna Smith, to name just a few. Each of these parents had healthy babies who became autistic after vaccination.

I might have been like many of the officials within the public health community - denying a connection - had I not witnessed this tragedy in my own family. I might not have believed the reports from parents like Scott and Laura Bono, Jeff Sell, Jeff and Shelly Segal, and Ginger Brown, who came to me with pictures, videos and medical records. I might have been like so many pediatricians who discounted the correlation between vaccination and the onset of fever, crying, and behavioral changes. Because both of my grandchildren suffered adverse reactions to vaccines, I could not ignore the parent's plea for help. I could not ignore their evidence.

My only grandson became autistic right before my eyes - shortly after receiving his federally recommended and state-mandated vaccines. Without a full explanation of what was in the shots being given, my talkative, playful, outgoing healthy grandson Christian was subjected to very high levels of mercury through his vaccines. He also received the MMR vaccine. Within a few days he was showing signs of autism.

As part of our investigation, the Committee has reviewed ongoing concerns about vaccine safety, vaccine adverse events tracking, the Vaccine Safety Datalink (VSD) Project, and the National Vaccine Injury Compensation Program. I have joined with Congressman Weldon, Congressman Waxman and 32 other members of Congress in introducing HR 3741, the National Vaccine Injury Compensation Program Improvement Act of 2002 to realign the compensation program with Congressional Intent.

In today's hearing, we will receive a research update from several previous witnesses as well as new research findings that further support a connection between autism and vaccine adverse events. We will learn more about both the possible link between the use of the mercury-containing preservative thimerosal in vaccines and autism, as well as autistic entercolitis resulting from the Measles-Mumps-Rubella (MMR) vaccine.

Through a Congressional mandate to review thimerosal content in medicines, the FDA learned that childhood vaccines, when given according to the CDC's recommendations exposed over 8,000 children a day in the United States to levels of mercury that exceeded Federal guidelines. Is there a connection between this toxic exposure to mercury and the autism epidemic? We will hear from Dr. James Bradstreet and Dr. Vera Stejskal on this issue.

We have twice received testimony from Dr. Andrew Wakefield regarding his clinical research into autistic entercolitis. We will learn today that not only has he continued to conduct clinical research, but that this research is confirming the presence of vaccine-related measles RNA in the biopsies from autistic children. Dr. Wakefield - like many scientists who blaze new trails - has been attacked by his own profession. He has been forced out of his position at the Royal Free Hospital in England. He and his colleagues have fought an uphill battle to continue the research that has been a lone ray of hope for parents whose children have autistic entercolitis. Dr. Arthur Krigsman is joining us as well today to discuss his clinical findings of inflammatory bowel disorder in autistic children. He will share with us his initial findings as well as discuss his research plans currently with his Institutional Review Board for approval.

Do the epidemiological and case control studies, which the CDC has attempted to use to refute Dr. Wakefield's laboratory results, answer the autism-vaccine questions honestly? Epidemiologist Dr. Walter Spitzer is back today to answer this question. What else is needed to prove or disprove a connection?

Unfortunately, rather than considering the preliminary clinical findings of Dr. Wakefield as a newly documented adverse reaction to a vaccine, the CDC attempted to refute these clinical findings through an epidemiological review. While epidemiological research is very important, it cannot be used to disprove laboratory and clinical findings. Valuable time was lost in replicating this research and determining whether the hypothesis was accurate.

Officials at HHS have aggressively denied any possible connection between vaccines and autism. They have waged an information campaign endorsing one conclusion on an issue where the science is still out. This has significantly undermined public confidence in the career public service professionals who are charged with balancing the dual roles of assuring the safety of vaccines and increasing immunization rates. Increasingly, parents come to us with concerns that integrity and an honest public health response to a crisis have been left by the wayside in lieu of protecting the public health agenda to fully immunize children. Parents are increasingly concerned that the Department may be inherently conflicted in its multiple roles of promoting immunization, regulating manufacturers, looking for adverse events, managing the vaccine injury compensation program, and developing new vaccines. Families share my concern that vaccine manufacturers have too much influence as well. How will HHS restore the public's trust?

Access to the Vaccine Safety Datalink (VSD)

One of the primary topics to be discussed at this hearing is access to the Vaccine Safety Datalink. (VSD). To help fill scientific gaps, the CDC formed partnerships with eight large health maintenance organizations through an agreement with the American Association of Health Plans to continually evaluate vaccine safety. This project is known as the Vaccine Safety Datalink (VSD) and includes medical records on millions of children and adults. Up until this year, access to data from the VSD has been limited to researchers affiliated with the CDC and a few of their handpicked friends. This 'good old boy's network" practice has predictably led to questions about the objectivity of the research and the fairness of the results.

The VSD data should be made available to all legitimate scientific researchers so that independent studies can be conducted and results verified. This database contains a wealth of data involving millions of patients over a ten-year period. If properly utilized, it can help researchers study vitally important questions about the safety of vaccines, the effects of mercury-based preservatives in childhood vaccines, and many other questions.

The Committee first raised this issue with the CDC two years ago. For two years the CDC delayed. Six months ago, we were informed that the CDC was developing a plan to expand access to the database. Finally, in February of this year, after a great deal of prompting from the Committee, Dr. Robert Chen, Chief of Vaccine Safety and Development at the National Immunization Program, informed Committee staff that the CDC had finalized its plan and that it was poised to put it into effect. Under this plan, any legitimate scientist could submit a proposal to the CDC to conduct research using VSD data and access to the data would be provided along with some basic safeguards.

In preparation for today's hearing, Committee staff asked the CDC why the plan described to us in February had not yet been put into effect. The staff was informed that the plan had been put into effect. However, there had been no public announcement. How are researchers supposed to know about the availability of the data if there is no announcement? It took two years of prodding by this Committee to get the CDC to open up access to the database. For four months it appears that the CDC didn't inform anybody but this Committee of the data's availability.

That doesn't make it appear that the CDC is making a good faith effort to open up this database. It looks to me like the CDC is trying to do the bare minimum that they have to do to get us off their backs. That's not acceptable. That's why I insisted that Dr. Chen be here today. I just want to ask him why they didn't tell anyone about the database being available. I'd like to know how he expects researchers to use this data if nobody tells them it's available.

Dr. Roger Bernier is here from the CDC to testify about these issues. He is accompanied by both Dr. Chen, the creator of the VSD Project and Dr. Frank DeStefano, the CDC official who is also a co-author of the MMR - IBD study. They are here to address our questions on the VSD project and the vaccine- autism research. The CDC employees are accompanied by Dr. Stephen Foote of the National Institutes of Health and Dr. William Egan of the Food and Drug Administration."


But hey, we have an INTERNATIONAL group of scientists who say nothing is wrong....so I guess we parents should just bow down to the chemical gods and do whatever they say???

Jenny Hatch
Mother of five non-vaccinated children


5 posted on 10/20/2005 5:25:50 AM PDT by Jenny Hatch (Go Iraq Go!)
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To: Born Conservative

Sure, it's safe, as long as don't mind using drugs derived from the cells of aborted babies.

(And yes it was the 60s, but it's still going on. Just look at the chicken pox vaccine.)


6 posted on 10/20/2005 5:29:18 AM PDT by Eepsy
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To: Jenny Hatch

I know, I know. The difference between the lyme disease vaccine and the orwellian vaccines, is that the government wants to cover up the bad data to get its 'herd immunity'.

A better solution is to screen the less than one percent of the population that has the genetic markers. Less reactions, less of a hit on the vaers insurance fund. Everyone would win.

But the government would rather cover it up.


7 posted on 10/20/2005 5:35:28 AM PDT by fooman (Get real with Kim Jung Mentally Ill about proliferation)
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To: Jenny Hatch
JH: I have an autistic grandson and also work for the chairman of a Human Resources Committee in a state legislature. I only care about the truth and also care about a parent's right to make their own choices free of government mandates.

I'm keeping an open mind. I know they are removing thimerisol from vaccines. If this is true, then we should see a decrease in autism.

For years, we have been warned about the dangers of lead poisoning in children. We've been told lead causes learning and behavior disabilities. And yet, we've been removing children's exposures to lead and are our learning and behavior disabilities disappearing? I don't think so.

Who and what are we to believe?

8 posted on 10/20/2005 5:40:23 AM PDT by Conservativegreatgrandma
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To: Conservativegreatgrandma

It has been a difficult choice for our family, the pressure has been intense, but we have made this hard choice and decided to live with whatever consequences came.

I trust nature, I trust nutrition, I trust natural healing, herbs, oils, wellness, and I have a deep distrust of the whole medical community.

I am the one who has to live with the long term consequences of these choices. Not doctors or reasearchers or pharma manufacturers. I am the one who has to pay the medical bills, stay up all night with the sick baby, and deal with the unintended consequences.

So my CHOICE has been to say no to most of what medicine has to offer. For us, that choice has been a blessing. All five of our children are healthy and strong, both mentally and physically. But I don't take any of that for granted. I know the risks of the various diseases and plagues that are out there, that have been prophesied in the bible, are going to be a part of the world until the end times.

Would I vaccinate a child with the bird flu vaccine??? No I would not. Nor would I use the tamiflu drug. I trust living in harmony with nature.

Here are some more thoughts on this topic
http://www.naturalfamilyco.com/articles/flu_print.html

Good luck with your grandson. I have a dear friend with an autistic daughter and she has had good luck with a gluten free diet.

Jenny


9 posted on 10/20/2005 5:50:27 AM PDT by Jenny Hatch (Go Iraq Go!)
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To: Conservativegreatgrandma
I know they are removing thimerisol from vaccines. If this is true, then we should see a decrease in autism.

They actually removed Thimerosol from MMR several years ago (as well as from most of the other vaccines), yet the rate of autism is rising.

10 posted on 10/20/2005 6:00:27 AM PDT by Born Conservative (Don't take your organs to Heaven. Heaven knows we can use them here.)
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To: Jenny Hatch
Mother of five non-vaccinated children

I feel sorry for your children, although I respect your right to decide whether or not to vaccinate.

11 posted on 10/20/2005 6:01:48 AM PDT by Born Conservative (Don't take your organs to Heaven. Heaven knows we can use them here.)
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To: micho

Chiropractors have their place, just like MD's have their place. The two professions have been feuding for decades. My father was a chiropractor. Passed away 5 years ago. Listened to that spinal cure for many years.

There is also a Dr. Batmanheldij, who claims all diseases are caused from dehydration. Water is the cure to all diseases. He is an MD!

He has books out. One of which is called "Your body's many cries for Water".


12 posted on 10/20/2005 6:07:45 AM PDT by television is just wrong (http://hehttp://print.google.com/print/doc?articleidisblogs.blogspot.com/ (visit blogs, visit ads).)
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To: micho

A friend of mine, a chiropractor, did not get his two children vaccinated and they both had perfect attendance all throughout school.


13 posted on 10/20/2005 6:08:03 AM PDT by sarasota
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To: Jenny Hatch

Bravo Jenny Hatch! (Applause) My daughter will never have her two children "immunized". She prefers to build their immune systems through diet and exercise. Imagine that. A concept that is lost on most who eagerly anticipate each and every "magic bullet", be it an injection or the latest prescription drug.


14 posted on 10/20/2005 6:10:24 AM PDT by sarasota
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To: Jenny Hatch

A thousand thanks for the link. My daughter is a Naturopath and I've sent her a copy. We embrace natural healing.


15 posted on 10/20/2005 6:17:13 AM PDT by sarasota
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To: Jenny Hatch
I am the one who has to live with the long term consequences of these choices. Not doctors or reasearchers or pharma manufacturers. I am the one who has to pay the medical bills, stay up all night with the sick baby, and deal with the unintended consequences.

No mam, your children are the ones who have to live, or quite possibly die due to your 17th century attitude towards vaccination. Yes, 17th century, by the end of the 18th, vaccination was widely accepted.

So9

16 posted on 10/20/2005 6:23:33 AM PDT by Servant of the 9 (Trust Me)
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To: Born Conservative; All

"They actually removed Thimerosal from MMR several years ago (as well as from most of the other vaccines), yet the rate of autism is rising."

I'm sorry but that is incorrect. MMR never had thimerosal because it is a live-virus vaccine. As one parent of an autistic child said "Thimerosal (mercury) in vaccines loaded the gun and the MMR pulled the trigger".

To another poster who said that autism rates are still rising despite mercury being removed from vaccines - that is also incorrect. California was one of the first states to remove it and they have now shown 4 straight quarters of decline for the first time in 15 years. 15 years of steady increase in autism diagnoses that coincided with increased vaccines being given and now suddenly a steady decline.

Vaccine defenders will say it's due to some other factors ...but shouldn't we fund a definitive study to find out for sure? Ask anyone who has been a teacher for 20 years what they think. They will tell you that something is going on and that there's an explosion of autistic and learning disabled children. The rate is now 1 in 166. For those who claim that diagnosis is just better now, I'd ask them to show me where all of the 40 year old autistics are. I'd also point out that the Amish autistic rate is 1 in 10,000 like the old days. They are exempted from vaccinating their children on religious grounds.

This gov't is very busy protecting pharmaceutical & insurance companies from having to pay to treat this epidemic. The fact is that untreated autistics will have to be institutionalized when their parents die. We can either pay for treatments now or pay billions later to house these people. If vaccines are proven to have caused this illness then the moral thing to do is have a fund set up to treat these kids. If 1 in 166 children were being kidnapped in this country we would nuke someone. Well that's exactly what happens when a child becomes autistic.

I highly recommend any who are interested in this topic read "Evidence of Harm" by David Kirby. It's a very balanced view of this issue. I cannot recommend it strongly enough.

Do you remember the Mad Hatter in the Alice in Wonderland books? That was not a made up character. There was an expression in Victorian England that someone was "mad as a hatter" and there was a recognized illness called 'mad hatter's disease'. That's because hatters used a mercury based formula in hat making and the ones who could not process the mercury out of their bodies developed the symptoms of mercury poisoning.

I was pregnant with my 2nd son in 1991. That year the gov't warned pregnant women to reduce or eliminate their intake of certain fish that were high in mercury because of the effect on the developing fetus. That same year the gov't added an additional vaccine to the schedule and my son was given an HIB vaccine at birth that contained thimerosal. How crazy is that?!

Here are some facts that no one can argue with; mercury is a known neurotoxin. Mercury's affects are worse when body weight is lower and the brain is developing. It would cost an additional 30¢ to 50¢ per vaccine to have all vaccines in single dose vials or pre-filled syringes which would eliminate the need for a preservative like thimerosal.
Wouldn't any parent spend the extra few cents to avoid shooting that into their child?

The gov't is afraid to cause a panic by questioning the safety of vaccines that contain mercury. They do not want a rash of parents to decide against having their children vaccinated. I suggest that if it comes out that they've been lying and covering up, they will cause the very problem they hope to avoid.

Whether or not mercury causes autism has yet to be proven. But we do know that it is a neurotoxin. Why on earth would anyone choose to inject it into anybody when it is so easily avoidable? The public needs to demand mercury-free vaccines and the pharmaceitical companies will make them available.





17 posted on 10/20/2005 6:43:23 AM PDT by Dorian
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To: sarasota

Wow,
I'm so accustomed to being flamed when I chime in on this topic here at Free Republic, I was prepared for a general outbreak of fire...

Kudos to your daughter, your grandchildren are very lucky to have such an informed momma.

We can't forget natural childbirth in this discussion. Mother's who have been induced for Labor with a drug called Pitocin have also been linked to children who have ADD, learning disabilities and autism.

The thing is, the whole shootin match is toxic. From the drugs used during pregnancy (anyone read the recent stats about anti-depressants causing birth defects if used during the first trimester?) and then the whole cascading effect of drugs during labor and birth. All the toxins shot into the baby in the first week with early vaccines, and the biggest depleter of all - feeding babies with Formula.

If parents were given the facts about breastmilk and what it does for immunity the way they are propogandized about vaccines and formula, it would revolutionize our society.

I recently thought about weaning my two year old, but then decided to let him continue nursing as the absolute best defense against a deadly flu season. I am really curious to see how this flu season develops. But I know based on years of research that breastmilk is the absolute best offensive measure I can take for my babies health.

Jenny


18 posted on 10/20/2005 6:59:21 AM PDT by Jenny Hatch (Go Iraq Go!)
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To: Dorian

Thank you for stepping up and correcting the misleading evidence about thimerosal. As the rate of autism escalates, what is it going to take to get the attention of the skeptics in America? When are we going to get real with the protection the pharmaceutical companies have in DC with the lobbyists? We've become a nation tragic beyond belief when it comes to building health. Between pharmaceuticals and processed food, we're leading our citizens down the path to sickness and disease.


19 posted on 10/20/2005 7:20:08 AM PDT by sarasota
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To: Jenny Hatch

I have a question about Pitosin: is it also used to deaden pain during childbirth? Or is that another drug?


20 posted on 10/20/2005 7:22:13 AM PDT by sarasota
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