[Snurple]

A 22 cal auto with a 10 round clip (up close) would make the guy look like a colander in about 5 seconds. They tend to bounce around inside a body too.

[Paul Heinzman]

They tend to bounce around inside a body too.

It has a reputation of being the gun of choice for hit men. Penetrates the skull and then acts like that little ball inside an aerosol paint can.

[P8riot]

A 22 cal auto with a 10 round clip (up close) would make the guy look like a colander in about 5 seconds. They tend to bounce around inside a body too.

Also, if you happen to live where you can own a suppressor, a .22 makes a dandy weapon. Personally my main home defense weapon is a 12GA, but I have a .45ACP 1911 and a suppressed .22 on tap. Everything else is in the vault.