.22’s are under-rated.....
That said, the perps were surely amateurs and didn’t have time to assess granny’s firepower, while loading their baggy pants.
I have a .22 in my night stand drawer. A .22 Magnum.
(No, that’s not ALL I have in the house...;-)...)
Like the .22WMR, the 5mm has a projectile with an actual copper jacket, not a copper "wash" like the Long Rifle. As such, those bullets would penetrate better and deform less than a .22LR. Still not a "man-stopper" in the sense of knock-down power, but you might produce a gusher of an exit wound if you hit 'em in the right place.