Short of an armed insurrection, either through outside help (not going to happen under Obama) or ideally the Army staging a coup (which likely will trigger a civil war with the Guards), the entire regime won't go away with a wimper. Short of a miracle. I think the most promising prospect would be an Army coup hand-in-hand with civilian riots, protests and strikes.
It is pretty darn difficult to force people to work productively in technical jobs. They can't all be supervised and sabotage is often easy under those circumstances. The real issue is do they really have a commanding majority. If they do, then it is really only a matter of organization and will.