That is why Castro sent him to Bolivia.
Castro first sent Che to the Belgian Congo. The CIA backed the Congolese government with air support, ironically using many of the same Cuban-American pilots who fought valiantly at the Bay of Pigs. Once the Congolese efforts were defeated, Castro sent him to Bolivia...and decided to be a little more direct in getting rid of him.
When local Bolivian Communists contacted Castro to ask what level of support was expected of them, Castro’s reported answer was “Not even an aspirin!”