It reminds me a little of a rotten apple and a skull, perhaps a hint of the innocence lost after the Fall, but it also looks like one of those images of a nuclear blast taken microseconds after detonation:
The point is the two cities were judged by God and destroyed with fire for the sin of sodomy. This is a warning. Obama’s legitimization of homosexuality has put our country in danger. That city on fire in the painting could be America.