[Steely Tom]

I don’t think you can rely on pressure cooking alone to eliminate the threat from prions. Typically it needs to be combined with some extremely harsh phenol/chlorine/etc.

Yes, my recollection was that there had been a demonstration that CJD prions were still active after being heated to 600°C. However, I could not find that reference by a quick Google search.

[yefragetuwrabrumuy]

The tremendous irony of prions is that they are continually being created and destroyed in our bodies, and only a miniscule number have the exact combination to not be destroyed, to be able to convince similar proteins to mutate to become like them, and to survive the physical death of the body to strike again.

Which is why they are so associated with cannibalism.