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To: RinaseaofDs

Right, you posted some numbers in September, but not in June.

Do yo0u think we will have a billion infections by 2016?

“So, let’s go into 2015 - 2016, conservatively, as we are wont to do:

Jan 1, 2016 = 192M cases. By April you are at a billion cases.

Election Day, 2016 = Disease burns itself out because it ran out of people a couple of months ago (98.304 billion cases by Nov 1, 2016 based on monthly doubling)

All of this will be true IF the disease keeps doubling cases each month, which it has been since May 2014.

That should be an easier way for you to track where this is going based on the numbers WHO is publishing. You go up and look at what the Oct 1 number and you pray I’m wrong. When Nov 1 rolls around, do the same thing, and so on.”


21 posted on 10/30/2014 10:35:12 AM PDT by ansel12
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To: ansel12

There were, and always are, caveats with an infectious disease.

Epidemiology is math - differential equations. These equations essentially factor in the speeds of things.

If you have a tank filling with water, and the tank has an outpipe that is smaller than the inpipe, then the tank will still fill, but more slowly. That’s a simplified sort of model.

In Sep, three things were true:

1. The test for Ebola was not very good (still true)
2. There is no vaccine (still true enough - there are vaccines under development)
3. There are no serums or drugs effective against the disease (evidence suggests this may no longer be true. What is very true is that these drugs are not being used on a wide spread basis).

In Liberia, a doctor was successful treating Ebola Guinea with Lamivudine. There are others that ARE NOT ZMapp (when’s the last time you heard the word ZMapp) that have similar methods of action to Lamivudine that may be effective.

Black Agnes has a pretty good bead on the pharmaceutical angle.

The basic model breaks down in terms of three groups - Susceptible, Infectious, and Recovered

However, the model also has variables that impact it - like ‘Interventions’ and ‘Mortality’.

Interventions would be the use of quarantines, etc.

Mortality is, obviously, the dead. Eventually you run out of people to infect.

A big deal variable in this is called R nought, or R0, or the secondary infection rate. With this disease it only takes as little as 10 viruses in a droplet to infect a person. On top of that, we don’t really know when people start shedding the virus.

As long as R0 is bigger than 1, then the disease will continue to grow. Interventions drive the R0 less than 1, which means the disease will begin to burn itself out.

The current R0, globally, is about 2 - maybe higher given that the WHO is actively conditioning their figures (by a factor of 3).

AIDS drugs are being looked at as possible effective interventions. As for a vaccine, the REAL question is WHEN you can deploy it. For a vaccine to be effective in stopping a disease, you have to vaccinate enough people to choke out the number of Susceptible Class people from the path of the contagion. You can calculate the percent using R0:

1 - 1/R0, stated in percent, is the proportion of the population you need to vaccinate for the vaccine to stop the disease. If R0 = 2, then 1 - 1/2 = 50% need to be vaccinated.

That’s a lot of vaccine.

So, the long answer is:

1. If there is no vaccine by June 2015 - Yes.
2. If there is no effective drug intervention (AIDS drugs perhaps) - Yes.

Quarantines CAN WORK, and have worked throughout history. If we don’t quarantine, then again, Yes.

The disease will reach a tipping point - the disease popping up in too many places spreading too rapidly to contain without either a drug or a vaccine, and too fast to contain with a quarantine.

Or, we will come up with effective interventions. All my post did was indicate the mathematical pattern.


22 posted on 10/30/2014 11:19:33 AM PDT by RinaseaofDs
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