no, sorry factoryrat, Megantic was caused by not following the rules.
And; no one was on the train.
It was an easily preventable human error. The engineer/conductor (one in the same) didn’t tie down enough handbrakes for the weight of the train, and left the automatic brakes set up and the locomotives running to keep air on the train. The locomotives shut down due to a fire on one of the units (poor maintenance). If there was a two man crew, the conductor would work with the engineer to set the required amount of handbrakes on the cars.
If you tried to pull that shit on a class one railroad in the US, you would literally be fired on the spot.
If there had been a second crew member, there would have been someone else to confirm that all the rules were followed and help to set more brakes.
If there had been a second crew member it might not have been necessary to leave the train unattended, something which is probably a very bad idea whenever there is hazardous cargo.
If there had been a second crew member, someone might have been there to observe when a fire started in the locomotive, firemen shut off the engine, and the train eventually started to move downhill.