Of course Twitter hates him- since he’s right.
Factually though, attempts to compromise were ongoing from before the Revolutionary War. Notably, during negotiations over Virginia handing over it’s NW Territories to the feds a deal was reached which would have ended slavery- only to be vetoed by South Carolina which was totally dependent on slavery.
Then the states of the NW Territories were bound to the North by the Erie Canal and the slave states were doomed- these descendants of Virginia fought on the North’s side. The side they were economically bound to.
Of course compromises which are, today, commonplace were never even thought of: such as federal money to reimburse the slave owners for their losses.
That turned into a good deal for the North since they got everything of value in the South in the end.
Cotton prices and profits were rising in the 1850s. Cotton planters thought the boom would last forever. Elites in the slave states convinced themselves that slavery was a good thing, the foundation of civilization. They weren't going to take federal money to give up their slaves. Given their expectations, it didn't make economic sense.