It is a federal crime to own/grow marijuana. Obama era EOs and regulations ignoring laws on the books (like immigration) is not the way to run a country. What happens when another state wants to ignore gun laws? Environmental laws? Tax laws? Etc. CHANGE THE LAW and don’t blame those whose job it is to ENFORCE the law.
So if fedgov trampled the Second Amendment, would you bend over as easily as you just bent over for a trampling of the Tenth?