I only really have three issues with marijuana:
1. There should be harsh penalties for anyone who smokes it somewhere that someone else could be affected by it
2. Anyone DUI marijuana should not be allowed to drive again
3. It shouldn’t be permitted in public places, schools, or workplaces
If it is used exclusively in private residences by people who won’t be operating a vehicle, I don’t have a problem with it.
I do have a problem with Big Pharma stepping on natural remedies because they don’t want competition for the toxic garbage they sell.
From the DUI standpoint, a problem is that blood levels don't correlate with degree of impairment as well as they do with alcohol. This makes it more problematic to convict. Predictably, states with legal marijuana use have seen an increase in accident fatalities.
(Advisable to drive a big safe car, truck or SUV. When I worked in DC -- during the Reagan years -- a problem was drunk diplomats driving big Benzes. They could kill you, and walk.)