Free Republic
Browse · Search
News/Activism
Topics · Post Article

To: NobleFree
And yet is being overcome.

Nope. Unless a person has consumed so much alcohol that his life is in immediate danger without medical attention, he has not overcome his body's natural ability to destroy and remove alcohol.

So dizziness is not an effect of mild or moderate alcohol toxicity - toxicity kicks in only when one requires medical attention? Sounds fishy to me.

Only because you have not studied toxicology.

And, I think I will take this opportunity to point out that while you keep making a big deal about how feeling the effects of having a drink must be a sign of how toxic alcohol is, I can't help but notice that you are avoiding making any kind of statement about how feeling the high from marijuana must also be a sign of toxicity. Delta-9-tetrahydrocannabinol, FYI, has an LD50 about 10 times lower than alcohol. That means that it is about 10 times as toxic as alcohol, since the lower the LD50 is, the more toxic a substance is.

Is "direct proximity" the same as binding? Is there any evidence for mental effects of lipid-stored THC? As far as I know, the answers are no and no.

The fact that it is in direct proximity to a target molecule means that it is available to bind, and that it does spend a certain amount of time bound to the target. The specific amount of time it spends bound vs. not bound can only be determined by some heavy duty kinetics experiments, interpreted through complicated logarithmic functions, so I do not and cannot have the information necessary to estimate the ratio of bound/unbound THC, or to know to which molecules it is binding. In order for THC to have effects on neurological function, it is not necessary for the user to actually feel high. Those effects can occur through different pathways and affect neurological function that is not related to consciousness. For example, I do not think that hyperemesis syndrome is related to being high, but it is certainly a neurological outcome of using marijuana. In addition to receptors that are directly involved in the feeling of being high, there are thousands of other molecules in and on the cell--and what is the effect of marijuana chemicals on those other molecules? Does it affect gene expression? Does it damage DNA? Does it interfere with other metabolic pathways that are necessary for cell survival? Etc. A substance does not have to cause altered consciousness to be harmful.

82 posted on 05/29/2018 5:06:40 PM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
[ Post Reply | Private Reply | To 72 | View Replies ]


To: exDemMom
Unless a person has consumed so much alcohol that his life is in immediate danger without medical attention, he has not overcome his body's natural ability to destroy and remove alcohol.

Obvious nonsense - if one is feeling alcohol's effects, the affecting alcohol molecules by definition got past the body's destroying and removing.

you keep making a big deal about how feeling the effects of having a drink must be a sign of how toxic alcohol is

No, that's your straw man.

Delta-9-tetrahydrocannabinol, FYI, has an LD50 about 10 times lower than alcohol.

Is that by weight? If so, it's a meaningless comparison - the relevant one being LD50 weight as a percentage of typically consumed weight.

And since they've never succeeded in killing a lab animal larger than a rat with THC, that LD50 must be a large leap of extrapolation. There is no documented case of a human being dying from the proximate cause of consuming too much THC ... very much unlike alcohol.

85 posted on 05/29/2018 6:17:34 PM PDT by NobleFree ("law is often but the tyrant's will, and always so when it violates the right of an individual")
[ Post Reply | Private Reply | To 82 | View Replies ]

Free Republic
Browse · Search
News/Activism
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson