Are you saying Down Syndrome is meant to be, by Gd? Maybe it is. I can’t begin to understand. I know from caring with people with special needs that they are perfect just the way they are. I think Gd sets up the world and things just combine in weird ways, obstacles happen, and we must get through them, get past them, and love each other.
There is a very short window of time toward the later part of the first trimester, in which the brain / sex organ / gender / decisions are made. Clearly something environmental affects some of those determinants. There are more gender dysphoria, more homosexuality, more hypospadias, more ovarian problems, than generations before.
Not everyone gay chooses to be gay. Most do not.
I think it's best to say most do not choose their same-sex attraction, but neither are they born with their same-sex attraction. That's what science and all the data supports. When we ignore all the data, we become similar to mushrooms: in the dark, surviving off manure and spouting the same.
Don't be like a mushroom.