We can forfeit Collins and Murkowski, but no one else.
I don’t see either of them not voting to confirm him. Murkowski especially - she represents a Republican state Trump easily carried - it benefits her politically to vote to confirm and certainly doesn’t hurt her.
It also doesn’t harm Collins politically to vote to confirm a Supreme Court justice - she has voted to confirm all of them I believe since she has been in the Senate for every President that has appointed one. Not to mention Trump came close to winning in Maine and even took one of the Electoral votes - first time since 1984 a Republican had gotten an electoral vote from Maine.
Although just the same, losing that Alabama Senate seat because of Sessions being appointed AG and us nominating a horrifically bad candidate is the reason we have to even think about this. Pence had to break ties before when we had 52 seats with them both defecting...but now if they both defect on a party line vote we lose.