Two Republicans voted "NO" in the Clarence Thomas confirmation vote in 1991. That was the last time a Republican Senator every cast a "NO" vote in a confirmation vote for a Supreme Court justice nominated by a Republican president.
I think that streak is still alive if Murkowski voted "Present" today.
Old John Warner of VA cast a “no” on Judge Bork in 1987. Thereafter he became a full-fledged liberal.