I’ve often heard, that the Kerry/Edwards ticket of 2004, is likely the last Democrat presidential ticket with two white presumably heterosexual men.
If Joe Biden or Beto O’Roarke became the Democrats nominee, he will be under immense pressure to pick a member of minority group, and/or a woman, as a running mate.
I expect the same to happen with the GOP in 2024, that they will be under pressure to avoid a ticket with two white presumably heterosexual males.