Posted on 03/24/2020 12:35:18 AM PDT by kire555
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome cor- onavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local economies. As of March 3, 2020, over 80,000 cases have been confirmed in China, including 2946 deaths as well as over 10,566 confirmed cases in 72 other countries. Such huge num- bers of infected and dead people call for an urgent demand of effective, available, and affordable drugs to control and diminish the epidemic. We have recently reported that two drugs, remdesivir (GS-5734) and chloroquine (CQ) phosphate, efficiently inhibited SARS-CoV-2 infection in vitro...
(Excerpt) Read more at mediterranee-infection.com ...
Interesting
Hopefully, it will help. So far, it appears that recoveries will take a long time, for those who do recover.
https://en.wikipedia.org/wiki/2019%E2%80%9320_coronavirus_pandemic#Epidemiology
United States
Cases 46,447
Deaths 587
Recoveries 315
Italy
Cases 63,927
Deaths 6,077
Recoveries 7,432
[Some have committed the fallacy of comparing numbers of deaths to the total population instead of against the numbers of cases after complete resolutions of those cases. Policies and levels of adherence to those policies will determine the numbers of cases and deaths. The same individuals have committed the fallacy of dividing the current death totals by the total numbers of cases, even though most of the cases have not concluded, yet.]
Thanks for the post. BTTT.
Even then, these class of drugs are dangerous in terms of potential side effects...D go grabbing the fish tank cleaner and chow that down. yikes!
Good, you first doc. I remember chloroquine and this is not a good time for DIC with a shortage in blood.
“Even then, these class of drugs are dangerous in terms of side effects”
No, they are not according to the CDC and WHO
The safety profile of hydroxychloroquine is actually quite good. I know three people who have been taking hydroxychloroquine for several years to treat lupus or rheumatoid arthritis. My friend who has been taking it for her RA has been on the drug for over 10 years and hasn’t had the first problem.
According to the CDC, the risk of toxicity in the first five years for someone without special risk factors is very low and measurable impairment from retinal toxicity occurs in less than one out of five thousand patients on extended regimens at standard doses. Hydroxychloroquine is not even in the top 100 drugs for retinal toxicity according to the National Registry of Drug-Induced Ocular Side Effects.
According to the CDC, off-label “compassionate use’ protocols on treatment of Covid-19 using Hydroxychloroquine have been consistent with recommendations for treatment of lupus and rheumatoid arthritis with some variation; 400mg BID on day one, then daily for 5 days; 400 mg BID on day one, then 200mg BID for 4 days; 600 mg BID on day one, then 400mg daily on days 2-5.
In conclusion, the six day treatment regimen for resolving cases of SARS-CoV-2 should pose little danger for patients other than those that have special risk factors... and all patients would be pre-screened to identify those risk factors as part of the protocol for determining suitability for treatment using hydroxychloroquine as a matter of course.
In vitro means in a test tube. Unfortunately, this isn’t all that meaningful. A shot of vodka will also kill the bug in a test tube. But drinking vodka won’t help cure someone infected with the bug.
[Even then, these class of drugs are dangerous in terms of potential side effects...D go grabbing the fish tank cleaner and chow that down. yikes!]
The toxicity of chloroquine and hydroxychloroquine are significantly different (the hydroxy version much less so).
Most drugs are dangerous if misused, especially prescription drugs.
Anyone who treats themselves with “fish tank cleaner” is an idiot and a prime candidate for a Darwin Award.
Anyone who uses that sort of stupidity to slam Trump is also an idiot and helping to do the work of the corrupt anti-American leftist media and the equally corrupt democRat party.
Quinine was discovered from the bark of the Cinchona plant.
You can buy capsules of ground-up Cinchona bark. My wife and I are each taking one capsule daily through this period.
Yes, it is the precursor, but I avoided the Swine (H1N1) flu by grinding up dried star anise and mixing a teaspoon full into a little yogurt. Star anise is the natural medicine that was refined into Tamiflu.
“You can buy capsules of ground-up Cinchona bark. My wife and I are each taking one capsule daily through this period’
Pretty much out of stock everywhere, the word is out. Not sure I will receive the bottle I ordered on the 20th from Amazon. The shipping date had been moved out and the 3rd party sellers is sold out.
No, they are NOT. Side effects are rare, as shown by literally MILLIONS of people having taken the drug for malaria preventative (including my sister-in-law).
Taking a fishtank additive is just plain stupid.
Bravo...excellent factual post.
Please don’t confuse the naysayers with facts!
What about Quercetin with bromelanin? OTC quinine....or how about tonic water with quinine in it?
In vitro studies are good to identify possible potential for in vivo (living) effectiveness. I believe there are a few studies being conducted with rapid data input which will shed more light on hcq position in the battle soon.
IIRC quinine water by law has no more than 83mg. per liter...so it is not too much. A 325mg dose is close to 4 liters....interesting fact....adding gin and other ingredients to quinine helped malaria sufferers take the medicine back in the day...hence the invention of gin and tonic.
Totally agree. There are thousands of chemicals that cure cancer "in vitro", that don't work in the human body.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.