Posted on 04/24/2020 1:14:42 PM PDT by ProtectOurFreedom
...I was just searching for advice on when to use Chloroquine and when to use HCQ. Wiki says “Hydroxychloroquine has similar pharmacokinetics to chloroquine”
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Yes, Hydroxychloroquine has the medical benefits that Chloroquine has but without all the bad side effects that Chloroquine can have, The DISTINCTIONS between the two drugs are VERY important.
IMHO, Chloroquine should NOT be used where Hydroxychloroquine is available. To do so is, again IMHO, a knowing act of sabotage of a clinical trial.
wrong. It’s both. plaquenil and azithro both increase the qtc. we are only giving doxycycline with the plaquenil in covid patients
There are many drugs that have the same cardiac effects. The real trouble comes when someone has a long QT interval already or you start stacking the drugs
sinc deficiency is vanishingly rare in this country, so much so that is is case reportable
hydroxychloroquine also causes hemolytic anemia when given to someone with G6PD deficiency
And these clowns are the administrators of our national drug program, I’m scared.
Sheesh...trying to elicit sympathy. Tough crowd here. Might ornery of you.
Brazilians.
The HCQ story begins in 1638 when the wife of the Viceroy of Peru, Countess Cinchona, acquired malaria while living in the New World. Rather than getting the “approved” therapy, blood-letting, she was treated by an Incan herbalist with the bark of a tree (eventually, named for the countess-Cinchona Tree). Her response was dramatic; when the Viceroy returned to Spain, he brought with him large supplies of the powder for general use, which at the time was controlled by the Church and was thus called “Jesuit’s Powder”.
The Nine Lives of Hydroxychloroquine
http://rheumnow.com/blog/nine-lives-hydroxychloroquine
You are absolutely correct.
The problem is about the efficacy of prophylaxis.
The mosquitos are adapting to CQ after 75 years and no longer used.
When I was in RVN they added one small white pill daily from (IIRC) one large pink pill a week for this problem.
A side note:
Distant kin that works in a hospital tested positive for Wu-flu, a few days into quarantine developed breathing problems. On admittance to the hospital was given CQ and put on oxygen. Released in a couple of days, more quarantine and just this week returned to work.
The Nine Lives of Hydroxychloroquine
A nice find, thanks.
“sinc deficiency is vanishingly rare in this country, so much so that is is case reportable”
Is it really? I found this in my reading. The study cited is from 1993, so maybe there’s more zinc fortification in food nowadays. Here’s the paper that cited the study. I thought the sections on mild zinc deficiency (page 179), the therapeutic impact of zinc (page 180), and zinc supplementation in the elderly (page 183) were particularly interesting. It seems to me that zinc supplementation might be useful in boosting the immune system and lessening inflammation at little risk, but I’m no doctor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649098/pdf/176.pdf
“The daily intake of zinc in elderly subjects in the Western world including the United States is only w8–10 mg, whereas the RDA is 15 mg. The elderly frequently do not eat the usual 3 meals a day and skip either breakfast or lunch. Many live alone and do not cook a proper meal for themselves. Our study in the Detroit area showed that 35% of the well-off ambulatory elderly subjects may have a deficiency of zinc based on their plasma zinc levels. Zinc deficiency and susceptibility to infections due to cell- mediated immune dysfunction have been reported to occur in the elderly (75,76). The third NHANES (1988–1914) also found that elderly persons (older than 71 y) were at the greatest risk of inadequate zinc intake (77).”
In this case I don’t care about mosquito’s and how well it treats malaria. I care about treating Covid 19. The point is that the flyer advertises Chloroquine as safe. And the Hydroxy version of it is even safer.
another study designed to show failure of CQ/HCQ ... all doctors worth their salt know that antivirals are most effective only when given within 24-48 hours of the onset of symptoms, e.g., tamiflu for influenza and famciclovir for shingles ...
i’ve noticed that every one of these “studies” coming out dealt ONLY with giving CQ/HCQ to critically ill patients, which is indeed basically to late for them to usually have any positive effect ...
and yes:
1. it’s well known that CQ is substantially more toxic than HCQ
2. zith is what prolongs QTc
again, two more parameters designed to cause failure ...
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