Starship will separate from it's massive booster once in orbit and it will splash down off the coast of Hawaii. I'm not sure about the booster but it will probably also splash down off the southern coast of the U.S. I don't think Musk will attempt a tower catch of the booster as is the goal ultimately.
Starship's "..3, 2, 1, Ignition" will be NERVOUS TIME yet the most exciting moment since the moon landing.
Kinda figured unmanned - thanks for the info