I lean towards transhumanism as the stuff of which the Antichrist is made. (True AI is a subset of transhumanism.)
I wonder if The Mark of The Beast is Transhumanism and thus it makes people who take it “not human” and they can survive anything (Revelation 9:6). Christ didn’t die for non-humans, so they are damned.
I personally think the A/C and his false prophet might be Nephilim. Thus, why they are thrown immediately into the Lake of Fire upon Christ’s Return. They are the first to occupy it for 1,000 years before Satan gets his due reward too.