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Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials
Michigan Tech (very good school) but COLD ^ | Today | Mujeeb Olushola Shittu, Michigan Technological University, Olufemi Ifeoluwa Afolami, Michigan Tech

Posted on 05/13/2020 7:57:49 PM PDT by cba123

Abstract The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several precautionary measures have been prescribed to prevent further spread of the virus, which include avoidance of social gatherings, proper handwashing, frequently disinfecting of used items and surfaces and so on. More recent studies have highlighted the possibility of treating patients infected with the novel SARS-CoV-2 virus with chloroquine and hydroxychloroquine, of which mechanism of action is not completely understood. We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease.

Publication Title Le infezioni in medicina: rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive

(Excerpt) Read more at digitalcommons.mtu.edu ...


TOPICS: Business/Economy; Foreign Affairs; News/Current Events
KEYWORDS: coronavirus; hydroxychloroquine; michigantech; zinc
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To: absalom01; cba123

Actually my #20 was supposed to be replying to Absalom1 but it got folded up somehow.

And it was a YouTube link so I’ll record a backup copy of it because YouTube is on a rampage against anyone discussing this subject.


21 posted on 05/13/2020 9:22:37 PM PDT by Hostage (Article V)
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To: ProtectOurFreedom

Thank you for finding the full paper. I was struggling and double backed to ask and saw your link. Thanks again.


22 posted on 05/13/2020 10:10:51 PM PDT by Hostage (Article V)
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To: cba123

Anybody getting bored of this crap already?

Yes hydroxychloroquine works and works great and the government hates it because it’s cheap what else is new?


23 posted on 05/13/2020 10:40:05 PM PDT by Truthoverpower (The guv mint you get is the Trump winning express !)
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To: logi_cal869; All

> “Jokes aside, there IS a biochemical reason that hydroxychloroquine is ineffective without zinc.”

Zinc assures success. But in countries where the diet is zinc rich, zinc sulfate supplements appear not to be necessary. For example, Dr. Didier Raoult, MD, PhD in Marseille France has had success rates similar to Dr. Zelenko but without Zinc. On the other hand the French drink wine everyday with meals and wine has zinc.

If the blood plasma has a sufficient level of zinc, however it got there is not important, it just needs to be there,then the HCQ can work to push it into the cells.

In the USA, blood plasma levels of Zinc are on average likely to be lower than those of France. So a Zinc supplement ensures the plasma is loaded such that HCQ can push it into the cells, into the pneumocytes.

If it’s me, I would take Zinc supplements just to be sure regardless of my plasma Zn level . I might substitute Zinc picolinate in place of Zinc sulphate. Zn picolinate is organic, more easily absorbed.

Foods that are loaded with Zinc:

Oysters
Crab
Mussels

Also nuts like Cashews.

Study which foods are rich in Zinc and change habits to get them in your diet. Snack on cashews, graze on seeds like squash seeds, sesame seeds, and pumpkin seeds, salted and roasted is Ok.

Zinc improves the immune system. It’s required for the functions of over 300 enzymes.
It metabolizes nutrients, maintains your immune system.

It’s also found in red meats and chicken. But purchase only organic grass fed red meats and free range chicken.

Also consider drinking tonic which contains quinine. HCQ derives from quinine. If the tonic is not tasty, add sweetener. I like Monk Fruit sweetener. I don’t do gin, don’t do any alcohol.


24 posted on 05/13/2020 10:43:20 PM PDT by Hostage (Article V)
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To: cba123
Hydroxychloroquine has at least two modes of efficacy in treating covid patients in the first five days of their infection:

1) As proven over sixty years, Hydroxychloroquine reduces inflammation, proven with Lupus and RA patients taking far more HCQ that treating covid;
2) Hydroxychloroquine has been proven to be a zinc ionophore at the ACE@ recptor sites where covid like to enter the cell for replication, and the zinc stops the replication cycle and thus reduces the viral load early in the disease.

A third mode by which HCQ might be inhibiting viral load is docking at ACE2 receptor sites and the virus loses places to dock on cells.

25 posted on 05/13/2020 10:49:35 PM PDT by MHGinTN (A dispensation perspective is a powerful tool for discernment)
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To: KarlInOhio

FDA will likely not allow it.


26 posted on 05/13/2020 10:51:02 PM PDT by MHGinTN (A dispensation perspective is a powerful tool for discernment)
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To: KarlInOhio

There is micro bead technology in pharma that can put both in a capsule so the release can be meted out at varying intervals, like the HCQ first then later the zinc rush. The technology is already used in theophylline and potassium dosing, and several other meds.


27 posted on 05/13/2020 10:53:44 PM PDT by MHGinTN (A dispensation perspective is a powerful tool for discernment)
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To: Hostage

Sure. It’s a good review paper with lots of explanation of the role of zinc fighting other viruses and cancer cells.


28 posted on 05/13/2020 11:28:32 PM PDT by ProtectOurFreedom
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To: Hostage

msm/dems, most in fedgov and also leftist local and State politicians are criminally insane


29 posted on 05/14/2020 6:13:02 AM PDT by Pollard (whatever)
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To: ProtectOurFreedom

CONCLUSION

Chloroquine can induce the uptake of zinc into the cytosol of the cell, which is capable of inhibiting RNA-dependent RNA polymerase and ultimately halting the replication of coronavirus in the host cell. Currently, there are several clinical trials that are currently underway in several countries of the world to assess the efficacy of chloroquine as an anti-coronavirus agent. Since chloroquine has been widely prescribed for use as an anti-malar-ial, its safety is not in doubt. In view of the fore-going, clinical trials predicated upon a synergis-tic administration of Zn supplement with CQ or HCQ against the novel SARS-CoV-2 virus should be considered so that better COVID-19 clinical tri-al outcomes can be obtained going forward.

“””Since chloroquine has been widely prescribed for use as an anti-malar-ial, its safety is not in doubt.”””

Except by the dems/msm due to TDS. Who cares if people die - #RESIST


30 posted on 05/14/2020 6:17:01 AM PDT by Pollard (whatever)
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To: cba123

Added to the collection

From a search done for hydroxychloroquine here on FR

"Anecdotal"

https://losangeles.cbslocal.com/2020/04/16/newport-beach-elderly-coronavirus-survivors/
https://abc7.com/health/doctors-say-caution-needed-in-drug-treatment-for-covid-19/6082485/
https://aapsonline.org/hcq-90-percent-chance/
https://www.thegatewaypundit.com/2020/05/80-patients-staff-members-come-coronavirus-texas-nursing-home-hydroxychloroquine-treatment-saves-1-patient/
https://www.wsbradio.com/news/local/video-year-old-covid-survivor-shares-his-story/BJlgWl3F7W5jcb8G79xycL/
https://www.gazettextra.com/news/local/local-woman-details-her-battle-with-covid-19/article_49490ada-6e2f-5e9f-b8ce-29051941d3d8.html
https://techstartups.com/2020/04/08/another-hydroxychloroquine-success-story-dr-marc-siegel-says-hydroxychloroquine-cured-96-year-old-father-coronavirus/
https://www.youtube.com/watch?v=GUpTxZrEaAM&feature=emb_logo
https://www.miindia.com/blog/details/michigan-doctor-treats-himself-to-beat-covid-19-1002
https://www.ntd.com/teen-challenge-pastor-recovers-from-covid-19-after-hydroxychloroquine_456727.html
https://losangeles.cbslocal.com/2020/04/21/torrance-doctor-recovers-from-coronavirus-credits-z-pack-zinc-hydroxychloroquine-treatments/
https://www.silive.com/coronavirus/2020/04/si-coronavirus-diary-this-covid-19-survivor-says-hydroxychloroquine-helped-save-his-life.html
https://www.wamc.org/post/covid-19-survivor-i-was-ready-die
https://www.pix11.com/news/coronavirus/102-year-old-grandma-with-that-tough-new-york-spirit-survives-covid-19
https://www.news-medical.net/news/20200419/Hydroxychloroquine-and-azithromycin-treatment-in-80-COVID-19-patients-short-term-outcomes.aspx
https://www.cbsnews.com/news/will-hydroxychloroquine-help-fight-covid-19-one-trial-is-trying-to-find-out/
https://www.washingtonexaminer.com/news/elderly-woman-99-on-track-to-recover-from-coronavirus-after-taking-hydroxychloroquine

General Info

https://www.indiatvnews.com/news/india/india-providing-hydroxychloroquine-drug-over-50-countries-coronavirus-full-list-608345
https://nypost.com/2020/04/02/hydroxychloroquine-most-effective-coronavirus-treatment-poll/
https://www.washingtonexaminer.com/opinion/op-eds/stop-using-hydroxychloroquine-to-politicize-physicians
https://internetprotocol.co/hype-news/2020/04/30/covid19-explanation-hcq-works/ (only 20 out of 65,000 Lupus patients get covid-19 - they take HCQ)

Trials and other country’s usage

https://www.infezmed.it/media/journal/Vol_28_2_2020_9.pdf
https://www.telegraphindia.com/world/zinc-hope-in-corona-fight/cid/1771935 (Results - HCQ/Z-pak/zinc good)
https://www.reviewjournal.com/life/health/las-vegas-hospital-blazes-own-path-with-malaria-drug-to-treat-covid-19-2005095/
https://www.financialexpress.com/lifestyle/health/russia-to-treat-virus-cases-with-anti-malaria-drug-hydroxychloroquine/1931775/
https://www.scnow.com/news/health/hydroxychloroquine-trial-set-to-launch-at-musc-health/article_0ce32f0e-2fe1-56ba-956d-7158dc20c582.html
https://www.eurekalert.org/pub_releases/2020-04/uoc—cta043020.php
https://surfguardcr.com/local-news/costa-rica/costa-rica-prescribing-hydroxychloroquine-for-covid-19-patients
https://translate.google.com/translate?sl=it&tl=en&u=https%3A%2F%2Fwww.ilfattoquotidiano.it%2F2020%2F04%2F28%2Fcoronavirus-da-nord-a-sud-1039-pazienti-trattati-a-casa-con-idrossiclorochina-il-punto-sulla-sperimentazione-crollo-dei-ricoveri%2F5783544%2F
https://www.redstate.com/elizabeth-vaughn/2020/04/23/french-doctor-didier-raoult-cites-flaws-scientific-misconduct-in-recent-va-study-on-hydroxychloroquine/
https://www.heartland.org/news-opinion/news/hydroxychloroquine-clinical-trials-effective-in-silencing-american-media
https://www.india.com/news/india/coronavirus-mumbais-dharavi-to-become-indias-stage-for-hydroxychloroquine-experiment-4005790/

Fauci’s NIH

https://thehill.com/policy/healthcare/494012-nih-recommends-against-combining-hydroxychloroquine-with-z-pak-to-treat

31 posted on 05/14/2020 6:21:46 AM PDT by Pollard (whatever)
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To: cba123

Bookmark


32 posted on 05/14/2020 6:27:08 AM PDT by landerwy (Who has the Trump card?)
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