.22 has it’s uses and there are a lot of them.
I read recently of Israeli special ops taking out ringleaders with silenced Ruger 10/22 rifles. They also seem to like Beretta model 70 .22 pistols for assassinations.
If there are a lot of heavily armed people with bullet proof vests etc. I will simply run away. If it is only a few and I know they intend to kill me or mine. I would use my old Swedish Mauser. I have 20 boxes of Lapua 6.5 match and a few boxes of Norma hunting ammo.
Back in the 1980s, there was a gun magazine called FIREPOWER which showed how to make full auto firearms and silencers. For a silencer, it was found that two liter soda bottle hose claimed on the end of a .22 did a good job for several rounds.
Well lookee heah, lookee heah! I still got those old FIREPOWER magazines!