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Karl Deisseroth is leaving his mark on brain science one technique at a time. When Karl Deisseroth moved into his first lab in 2004, he found himself replacing a high-profile tenant: Nobel-prizewinning physicist Steven Chu. “His name was still on the door when I moved in,” says Deisseroth, a neuroscientist, of the basement space at Stanford University in California. The legacy has had its benefits. When chemistry student Feng Zhang dropped by looking for Chu, Deisseroth convinced him to stick around. “I don't think he knew who I was. But he got interested enough.” Deisseroth is now a major name...

Vol. 330 no. 6011 pp. 1612-1613 DOI: 10.1126/science.330.6011.1612 News IntroductionTen years ago, Karl Deisseroth was stuck. A psychiatrist and neuroscientist, he wanted to learn how different brain circuits affect behavior—and what went awry in the brains of his patients with schizophrenia and depression. But the tools of his trade were too crude: Electrodes inserted into the brain would stimulate too many cells in their vicinity. So in 2004, Deisseroth and his students invented a new tool. They inserted a gene for a light-activated algal protein into mice brains, where it entered nerve cells. By stimulating those cells with a laser,...