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Florida Biochemist designs a citrus tree with THC
The Crit ^ | 05 Oct 2008 | The Crit

Posted on 01/05/2009 8:07:50 AM PST by BGHater

In the summer of 1984, 10th-grader Irwin Nanofsky and a friend were driving down the Apalachee Parkway on the way home from baseball practice when they were pulled over by a police officer for a minor traffic infraction.


After Nanofsky produced his driver’s license the police officer asked permission to search the vehicle. In less than two minutes, the officer found a homemade pipe underneath the passenger’s seat of the Ford Aerostar belonging to the teenage driver’s parents. The minivan was seized, and the two youths were taken into custody on suspicion of drug possession.

Illegal possession of drug paraphernalia ranks second only to open container violations on the crime blotter of this Florida college town. And yet the routine arrest of 16 year-old Nanofsky and the seizure of his family’s minivan would inspire one of the most controversial drug-related scientific discoveries of the century.

Meet Hugo Nanofsky, biochemist, Florida State University tenured professor, and the parental authority who posted bail for Irwin Nanofsky the night of July 8, 1984. The elder Nanofsky wasn’t pleased that his son had been arrested for possession of drug paraphernalia, and he became livid when Tallahassee police informed him that the Aerostar minivan would be permanently remanded to police custody.

Over the course of the next three weeks, Nanofsky penned dozens of irate letters to the local police chief, the Tallahassee City Council, the State District Attorney and, finally, even to area newspapers. But it was all to no avail.

Under advisement of the family lawyer, Irwin Nanofsky pled guilty to possession of drug paraphernalia in order to receive a suspended sentence and have his juvenile court record sealed. But in doing so, the family minivan became “an accessory to the crime.” According to Florida State law, it also became the property of the Tallahassee Police Department Drug Task Force. In time, the adult Nanofsky would learn that there was nothing he could do legally to wrest the vehicle from the hands of the state.

It was in the fall of 1984 that the John Chapman Professor of Biochemistry at Florida State University, now driving to work behind the wheel of a used Pontiac Bonneville, first set on a pet project that he hoped would “dissolve irrational legislation with a solid dose of reason.” Nanofsky knew he would never get his family’s car back, but he had plans to make sure that no one else would be pulled through the gears of what he considers a Kafka-esque drug enforcement bureaucracy.

“It’s quite simple, really,” Nanofsky explains, “I wanted to combine Citrus sinesis with Delta 9-tetrahydrocannabinol.” In layman’s terms, the respected college professor proposed to grow oranges that would contain THC, the active ingredient in marijuana. Fourteen years later, that project is complete, and Nanofsky has succeeded where his letter writing campaign of yore failed: he has the undivided attention of the nation’s top drug enforcement agencies, political figures, and media outlets.

The turning point in the Nanofsky saga came when the straight-laced professor posted a message to Internet newsgroups announcing that he was offering “cannabis-equivalent orange tree seeds” at no cost via the U.S. mail. Several weeks later, U.S. Justice Department officials showed up at the mailing address used in the Internet announcement: a tiny office on the second floor of the Dittmer Laboratory of Chemistry building on the FSU campus. There they would wait for another 40 minutes before Prof. Nanofsky finished delivering a lecture to graduate students on his recent research into the “cis-trans photoisomerization of olefins.”

“I knew it was only a matter of time before someone sent me more than just a self-addressed stamped envelope,” Nanofsky quips, “but I was surprised to see Janet Reno’s special assistant at my door.” After a series of closed door discussions, Nanofsky agreed to cease distribution of the THC-orange seeds until the legal status of the possibly narcotic plant species is established.

Much to the chagrin of authorities, the effort to regulate Nanofsky’s invention may be too little too late. Several hundred packets containing 40 to 50 seeds each have already been sent to those who’ve requested them, and Nanofsky is not obliged to produce his mailing records. Under current law, no crime has been committed and it is unlikely that charges will be brought against the fruit’s inventor.

Now it is federal authorities who must confront the nation’s unwieldy body of inconsistent drug laws. According to a source at the Drug Enforcement Agency, it may be months if not years before all the issues involved are sorted out, leaving a gaping hole in U.S. drug policy in the meantime. At the heart of the confusion is the fact that THC now naturally occurs in a new species of citrus fruit.

As policy analysts and hemp advocates alike have been quick to point out, the apparent legality (for now) of Nanofsky’s “pot orange” may render debates over the legalization of marijuana moot. In fact, Florida’s top law enforcement officials admit that even if the cultivation of Nanofsky’s orange were to be outlawed, it would be exceedingly difficult to identify the presence of outlawed fruit among the state’s largest agricultural crop.

Amidst all of the hubbub surrounding his father’s experiment, Irwin Nanofsky exudes calm indifference. Now 30-years-old and a successful environmental photographer, the younger Nanofsky can’t understand what all of the fuss is about. “My dad’s a chemist. He makes polymers. I doubt it ever crossed his mind that as a result of his work tomorrow’s kids will be able to get high off of half an orange.”

Biochem 101: How to design a Cannabis-equivalent citrus plant

Step One:
Biochemically isolate all the required enzymes for the production of THC.

Step Two:
Perform N-terminal sequencing on isolated enzymes, design degenerate PCR (polymerase chain reaction) primers and amplify the genes.

Step Three:
Clone genes into an agrobacterial vector by introducing the desired piece of DNA into a plasmid containing a transfer or T-DNA. The mixture is transformed into Agrobacterium tumefaciens, a gram negative bacterium.

Step Four:

Use the Agrobacterium tumefaciens to infect citrus plants after wounding. The transfer DNA will proceed to host cells by a mechanism similar to conjugation. The DNA is randomly integrated into the host genome and will be inherited.


TOPICS: Gardening; Science; Society
KEYWORDS: citrus; controlledsubstance; dna; dopersrights; fakebutaccurate; florida; floriduh; hoax; isureshowedthemhuh; janetreno; justicedepartment; narcotics; thc; thcoranges
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1 posted on 01/05/2009 8:07:51 AM PST by BGHater
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To: BGHater

O-kayyyyyyy.......


2 posted on 01/05/2009 8:12:57 AM PST by gimme1ibertee (Sarahlution!!!!!)
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To: BGHater

There are going to be a lot of sticky clogged up bongs in FL.


3 posted on 01/05/2009 8:16:09 AM PST by posterchild (Endowed by my Creator with certain inalienable rights.)
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To: BGHater

Wonder if he can patent the process. I didn’t see any mention of patents in the article, but I read through it pretty quickly.


4 posted on 01/05/2009 8:17:10 AM PST by jwparkerjr (God Bless America!)
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To: BGHater

Hey man, don’t bogart that orange man.


5 posted on 01/05/2009 8:17:19 AM PST by dblshot
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To: BGHater

What a jackass, all that effort because his sons a pothead.Typical irrational liberal behavior in otherwise “booksmart” people.
Guess all those starving people in Obama’s birth Continent have to wait in line for sustainable crops while Mr Nanofsky
rolls on the floor and kicks his smelly Birkenstocks in a tirade against Johnny Law and their unfair persecution of his stoned slacker spawn.


6 posted on 01/05/2009 8:17:19 AM PST by redstateconfidential (" An American Idol President")
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To: BGHater

Interesting.

I bet this would be a big plus for people who take medical marijuana, but don’t want to smoke it.


7 posted on 01/05/2009 8:17:21 AM PST by SoldierMedic (Rowan Walter, 23 Feb 2007 Ramadi)
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To: BGHater

Nanofsky, a petty, petty little man who could have spent his time and energy looking for a cure to heart disease or adolescent cancer — chose instead to use his time and talent to settle a petty dispute with “the man,” by producing an orange that will get kids high — “brilliant.”

What a “F’n” genius...I hope your Mom is proud of you Mr. Nanofsky...your contribution to the world is invaluable. Thanks dumbass...


8 posted on 01/05/2009 8:17:53 AM PST by areukiddingme1 (areukiddingme1 is a synonym for a Retired U.S. Navy Chief Petty Officer and tired of liberal BS.)
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To: posterchild
I thought it was banana peels that got you high...


9 posted on 01/05/2009 8:18:00 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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To: BGHater

Excellent outcome. An unjust law has backfired into a real mess. Would have been cheaper to return the guy’s van.

Superb!


10 posted on 01/05/2009 8:18:43 AM PST by DieHard the Hunter (Is mise an ceann-cinnidh. Cha ghéill mi do dhuine. Fàg am bealach.)
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To: redstateconfidential

um, this story is fake.


11 posted on 01/05/2009 8:18:43 AM PST by TornadoAlley3 (Obama is everything Oklahoma is not.)
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To: areukiddingme1

Note too that the article is hazy on the timeline. It is Janet Reno’s special assistant who came from the Justice Department. Meaning that this story is at least 8 years OLD.


12 posted on 01/05/2009 8:19:06 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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To: BGHater

If he can cross an orange tree with Grey Goose vodka, I’ll buy those seeds...


13 posted on 01/05/2009 8:19:42 AM PST by Buck W. (BHO: Selling hope, keeping the change.)
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To: TornadoAlley3

Now there will be a database tracking Orange tree sales.


14 posted on 01/05/2009 8:19:47 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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To: BGHater
Why do you need to search the car maaaaaan?
15 posted on 01/05/2009 8:20:16 AM PST by Troll_House_Cookies (Ironically, Chancellor Obama's first re-education camp will be in Alaska.)
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To: Buck W.

Want some magic beans?


16 posted on 01/05/2009 8:20:16 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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To: Troll_House_Cookies

"I'd hit it!" -B.Obama

17 posted on 01/05/2009 8:21:03 AM PST by weegee (Obamunism, just another word for the policies of a NeoCom.)
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To: jwparkerjr

I haven’t checked the USPTO website. But if it was done on university time and real estate with university resources, and if somebody in the legal department can imagine a commercial application for the product, you can bet the farm that a patent application was filed.


18 posted on 01/05/2009 8:21:47 AM PST by Philo1962 (Iraq is terrorist flypaper. They go there to die.)
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To: weegee

Don’t worry, The story isn’t real.


19 posted on 01/05/2009 8:21:54 AM PST by BGHater (Tyranny is always better organised than freedom)
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To: Buck W.

I’ve heard of martini’s with 4 or more olives called a Kennedy Salad. Perhaps this will get us on the road to a full salad bar.


20 posted on 01/05/2009 8:23:26 AM PST by posterchild (Endowed by my Creator with certain inalienable rights.)
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