New Agent Chokes Off Energy Supply, Kills Cancer Cells

The Ohio State University Medical Center ^ | Apr 7, 2010 | Darrell E. Ward

[decimon]

COLUMBUS, Ohio – Cancer cells grow so fast that they can outstrip their blood supply, leaving them short of oxygen. The cells then produce energy in a way that needs less oxygen but more sugar.

Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have designed an experimental drug that chokes off that sugar supply, causing the cells to self destruct.

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“Our study proves that this new agent kills cancer cells through energy restriction. This is important because it shows that it is possible to design drugs that target energy restriction, and it is exciting because energy-restricting mimetic agents may also be useful for other diseases, including metabolic syndromes, diabetes, cardiovascular disease and obesity,” Chen adds.

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To enhance that activity, they altered the structure of the ciglitazone molecule, producing OSU-CG12. Using prostate cancer and breast cancer cell lines, they showed that the new Ohio State agent was 10 times better at killing cancer cells than ciglitazone and a second agent, the drug resveratrol, a natural product found in grapes and red wine that has weak anticancer activity and also works through energy restriction.

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[Canedawg]

Maybe you can get a T-shirt made up that says, “It’s a side effect”

:-)

[Taffini]

Could you send me the source for the information? I know of a little kid who is fighting cancer.

[neverdem]

Energy Restriction as an Antitumor Target of Thiazolidinediones

Thiazolidinediones currently on the market are Actos and Avandia.

Thiazolidinediones (TZDs) are selective ligands of PPARgamma and act as insulin sensitizers.

[Ditter]

My husband a type 2 diabetic, was given Actos and it caused tremendous weight gain and kidney problems. Be careful with that stuff.

[goodwithagun]

The book is called Anticancer by Dr. David Servan-Schreiber. He is an MD and Ph.D. and a cancer survivor. The book is a pretty quick read and comes equipped with an appendix for quick reference. What I can tell you up front is: organic, grass fed meat, poultry, dairy, eggs (won’t get omega-3’s w/ reg. meat), organic veg and fruit when available (he’s not so much a stickler on this), whole grains, no sugar or sugar subs, no hydrogenated or partially hydrogenated oils (you must read ingredients on nutritional label). Also, since inflamation causes cancer cells to produce tumors and stress causes adrenaline and cortisol to inflame, he insists on counseling and various forms of relaxation to deal with stress. I’m greatly paraphrasing here, but get the book. It is only $16 at amazon.com and I bought several copies and gave them as Easter gifts to my parents and in-laws. It is really an eye-opener, and all of his info is footnoted so you can go directly to the source. He is not trying to sell snake oil. Actually, he’s not trying to sell anything.

[spectre]

"I just read Anticancer by Dr. David Servan-Schreiber. It is fascinating how what we put in our mouths affects cancer. He points out that hydrogenated oils, partially hydrogenated oils, and sugar feed cancerous tumors. Instead of taking a drug that blocks sugar, he has kept his very aggressive tumor at bay by simply not eating sugar."

Years ago, I recalled seeing a documentary on TV where they showed cancer cells in a Petri dish. They said they put sugar into the dish because CANCER needed SUGAR to survive and grow.

So when I had my serious bout with cancer, I eliminated all sugar. It was very difficult since most everything contains it. But I did it.

sw

[goodwithagun]

You should read his book. How many people don’t know what you know? It is a bit disturbing. This book has made a big difference in our lives, and we gave copies to my parents and in-laws for Easter.