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Glucosamine causes the death of pancreatic cells
Université Laval ^ | October 27, 2010 | Unknown

Posted on 10/27/2010 12:51:34 PM PDT by decimon

This release is available in French.

Quebec City, October 27, 2010—High doses or prolonged use of glucosamine causes the death of pancreatic cells and could increase the risk of developing diabetes, according to a team of researchers at Université Laval's Faculty of Pharmacy. Details of this discovery were recently published on the website of the Journal of Endocrinology.

In vitro tests conducted by Professor Frédéric Picard and his team revealed that glucosamine exposure causes a significant increase in mortality in insulin-producing pancreatic cells, a phenomenon tied to the development of diabetes. Cell death rate increases with glucosamine dose and exposure time. "In our experiments, we used doses five to ten times higher than that recommended by most manufacturers, or 1,500 mg/day," stressed Professor Picard. "Previous studies showed that a significant proportion of glucosamine users up the dose hoping to increase the effects," he explained.

Picard and his team have shown that glucosamine triggers a mechanism intended to lower very high blood sugar levels. However, this reaction negatively affects SIRT1, a protein critical to cell survival. A high concentration of glucosamine diminishes the level of SIRT1, leading to cell death in the tissues where this protein is abundant, such as the pancreas.

Individuals who use large amounts of glucosamine, those who consume it for long periods, and those with little SIRT1 in their cells are therefore believed to be at greater risk of developing diabetes. In a number of mammal species, SIRT1 level diminishes with age. This phenomenon has not been shown in humans but if it were the case, the elderly—who constitute the target market for glucosamine—would be even more vulnerable.

"The key point of our work is that glucosamine can have effects that are far from harmless and should be used with great caution," concluded Professor Picard.

The results obtained by Picard and his team coincide with recent studies that cast serious doubt on the effectiveness of glucosamine in treating joint problems.

###

This study was co-authored by Mathieu Lafontaine-Lacasse and Geneviève Doré.

Information: Frédéric Picard Faculty of Pharmacy Université Laval 418-656-8711 ext. 3737 frederic.picard@criucpq.ulaval.ca


TOPICS: Health/Medicine
KEYWORDS: cancer; diabetes; glucosamine; health; medicine; pharmaceuticals

1 posted on 10/27/2010 12:51:34 PM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith

Ping


2 posted on 10/27/2010 12:52:18 PM PDT by decimon
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To: decimon

Publish or perish.


3 posted on 10/27/2010 12:55:10 PM PDT by Check6 (United States of Moronia: A nation of morons ruled by a gang of communist thugs.)
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To: decimon

I use about 1/2 the suggested amount and it really makes a difference.


4 posted on 10/27/2010 12:57:36 PM PDT by SeaHawkFan
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To: decimon

Always curious about the funding of this type of research. Seems like a pretty random study - OR maybe a drug manufacturer designed a study to scare seniors out of using a more natural treatment. That said, moderation with supplements is probably a good rule to follow.


5 posted on 10/27/2010 1:04:28 PM PDT by JTHomes
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To: JTHomes
The results obtained by Picard and his team coincide with recent studies that cast serious doubt on the effectiveness of glucosamine in treating joint problems.

And who funded these also? Coincidence, or organized campaign to discredit a widely used supplement?

6 posted on 10/27/2010 1:06:34 PM PDT by JTHomes
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To: decimon

I take a couple a day since MERSA ate up my wrist. Makes all the difference in the world. What I can’t figure out is this: Those are BIG pills, shoving 10 to 20 of those babies down a mouse would seem to be a bit extreme and I would think would cause more problems than reported!


7 posted on 10/27/2010 1:12:05 PM PDT by Gadsden1st
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To: decimon

oh crap


8 posted on 10/27/2010 1:13:13 PM PDT by null and void (We are now in day 644 of our national holiday from reality. - 0bama really isn't one of US.)
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To: decimon

bttt


9 posted on 10/27/2010 1:14:26 PM PDT by diamond6 (Pray the Rosary to defeat communism and Obamacare!!)
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To: decimon

“In our experiments, we used doses five to ten times higher than that recommended by most manufacturers, or 1,500 mg/day.”

A poorly composed sentence.

Please note that 1,500 mg/day *is* the recommended dose, not 5 to 10 times the recommended dose, which would be 7,500 or 15,000 mg/day.

A “double-strength” glucosamine tablet has 500 mg. The recommended dose of 3 tablets a day is for *prevention* of joint problems. For *active* joint problems, a typical dose is 4 tablets a day, in two doses, for a total of 2,000 mg/day.

So for a human to get a dosage equivalent of causing harm “in vitro”, which means directly applied to cells, *not* yet shown to happen in even animal testing, would be to swallow between 15 and 30 of these pills a day.

That’s a lot of pills.


10 posted on 10/27/2010 1:19:14 PM PDT by yefragetuwrabrumuy
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To: JTHomes
And who funded these also?

You would question Picard? Where's that face palm picture?

11 posted on 10/27/2010 1:20:30 PM PDT by decimon
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To: decimon

sfl


12 posted on 10/27/2010 1:23:48 PM PDT by phockthis
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To: decimon

Not too sure about humans, but works great in aged dogs.


13 posted on 10/27/2010 1:24:56 PM PDT by Mashood
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To: decimon

bump for later.


14 posted on 10/27/2010 1:56:29 PM PDT by the crow (If I don't have a right to play defense, then I'll go on offense. - Enterprise)
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To: decimon

“The key point of our work is that glucosamine can have effects that are far from harmless and should be used with great caution,” concluded Professor Picard. “

ANY supplement can have effects that are far from harmless and should be used with great caution. My husband has very bad knees and is stalling his inevitable knee replacement surgery with glucosamine use, recommended by our doctor. Works wonders for him.

Would like to see more studies.


15 posted on 10/27/2010 2:30:53 PM PDT by Reddy (B.O. stinks)
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Comment #16 Removed by Moderator

To: Gadsden1st

After a few doses, the mouse no longer walks around so the arthritis is not so much felt ... roling randomly around doesn’t inflame the joints as much don’tchaknow.


17 posted on 10/27/2010 3:24:26 PM PDT by MHGinTN (Some, believing they can't be deceived, it's nigh impossible to convince them when they're deceived.)
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To: Wilburr

“As does Olive Oil (extra virgin) & hemp oil.”

My dogs get a tablespoon of olive oil every week. They love it! Where can you get hemp oil?


18 posted on 10/27/2010 3:28:53 PM PDT by Mashood
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Comment #19 Removed by Moderator

To: neverdem

ping


20 posted on 10/27/2010 3:36:06 PM PDT by GOPJ ('Power abdicates only under the stress of counter-power." Martin Buber /a Tea-nami's coming..)
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Comment #21 Removed by Moderator

To: Wilburr

Pretty interesting stuff.. but sounds like too much factory work.. ;0]


22 posted on 10/27/2010 3:43:24 PM PDT by Mashood
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To: decimon

OMG we are all going to die....I have taken 1000 mg a day for over 10 years and so has my dog....getting sick and tired of all the warning we are subject to.....


23 posted on 10/27/2010 5:38:46 PM PDT by goat granny
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To: goat granny

goat granny made a mistake, my dog has only been on it for a couple of years....me 10 years....


24 posted on 10/27/2010 5:40:34 PM PDT by goat granny
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To: decimon; AdmSmith; Arthur Wildfire! March; Berosus; bigheadfred; ColdOne; Convert from ECUSA; ...

I tried it — it made my joints ache. So I stopped using it. Colloidal minerals has worked for my joint pain in the past. Then the pain goes away, I stop taking a capful every morning, and...


25 posted on 10/27/2010 6:55:31 PM PDT by SunkenCiv (The 2nd Amendment follows right behind the 1st because some people are hard of hearing.)
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To: SunkenCiv
Colloidal minerals has worked for my joint pain in the past.

Am I blue
Am I blue
Ain’t these tears, in these eyes telling you

26 posted on 10/27/2010 7:05:18 PM PDT by decimon
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To: decimon; SunkenCiv; GOPJ; diamond6; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; ...
Hexosamines stimulate apoptosis by altering Sirt1 action and levels in rodent pancreatic β-cells

Inducing apoptosis causes cell death. FReepmail me if you want on or off the diabetes ping list.

27 posted on 10/27/2010 11:05:23 PM PDT by neverdem (Xin loi minh oi)
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bump!


28 posted on 10/28/2010 4:43:01 AM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: Wilburr
Wow, guess I will be cancer free for life.

Took mega doses from 1975 to 1978 LOL

29 posted on 10/28/2010 5:17:12 AM PDT by Popman (Obama. First Marxist to turn a five year Marxist plan into a 4 year administration.)
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Comment #30 Removed by Moderator

To: goat granny
In dog years you are probably correct. Note I just started taking Glucosamine and Chondroitin to see if it helps some hip pain I've started getting around age 59.

As with most of these studies if you take 100 times the normal amount yeah that's probably not smart.

31 posted on 10/28/2010 7:44:57 AM PDT by McGruff (A political party cannot be all things to all people. It must represent certain fundamental beliefs)
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To: McGruff

I hope it works for you, it sure works for me, if I forget to take it for several days I start with join pain again. As soon as I start taking it again, it goes away.. I found it takes a couple of weeks for it to kick in...for some its less time for some it takes a little longer...I buy the cheapest stuff by Schiff at wal mart...12.99 for 120 pills..


32 posted on 10/28/2010 10:13:50 AM PDT by goat granny
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To: neverdem

Simply - do you know if there are any results from this treatment with pancreatic cancer?


33 posted on 10/28/2010 5:25:48 PM PDT by freema (MarineNiece,Daughter,Wife,Friend,Sister,Friend,Aunt,Friend,Mother,Friend,Cousin, FRiend)
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To: freema
Simply - do you know if there are any results from this treatment with pancreatic cancer?

No. I just noticed your question. I'm sorry about the late reply.

34 posted on 11/09/2010 12:50:19 PM PST by neverdem (Xin loi minh oi)
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