The "Ruger Only" loads for 45 Colt can be quite stout. I have some that I loaded up for a Blackhawk that are quite satisfying - 26 grains of H110 under a 250 grain JHP bullet. Plus, the recoil pulse isn't as snappy as a .44 Mag.
That is pretty hot. I killed a black bear with my .44 mag. Three shots, first at 25 yds, last at the base if the tree I was in. Those were max loads of 24 grains of H110 under a 240 grain jacketed soft point. That same load showed pressure signs when fired from a friends .44 Super Blackhawk.
Can the New Vaquero handle that cup pressure?